Nanoscale colocalized thermal and chemical mapping of pharmaceutical powder aerosols

被引:0
|
作者
Zhang, Jing [1 ,2 ]
Khanal, Dipesh [3 ,4 ]
Chan, Hak-Kim [3 ]
Holl, Mark M. Banaszak [1 ,4 ,5 ]
机构
[1] Monash Univ, Dept Chem & Biol Engn, Clayton, Vic 3800, Australia
[2] Univ South Australia, Future Ind Inst, Mawson Lakes, SA 5095, Australia
[3] Univ Sydney, Fac Med & Hlth, Sydney Pharm Sch, Adv Drug Delivery Grp, Camperdown, NSW 2006, Australia
[4] Univ Alabama Birmingham, Dept Mech & Mat Engn, Birmingham, AL 35294 USA
[5] Univ Alabama Birmingham, Heersink Sch Med, Div Pulmonol Allergy & Crit Care Med, Birmingham, AL 35294 USA
关键词
Nanothermal analysis; AFM-IR; Pharmaceutical aerosols; Dry powder inhaler; Infrared spectroscopy; AFM; FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE; LACTOSE; CRYSTALLINE; INHALATION; MICROSCOPY; PARTICLES; INHALER; DRUGS; PHASE;
D O I
10.1016/j.ijpharm.2024.124116
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Inhalation of pharmaceutical aerosol formulations is widely used to treat respiratory diseases. Spatially resolved thermal characterization offers promise for better understanding drug release rates from particles; however, this has been an analytical challenge due to the small particle size (from a few micrometers down to nanometers) and the complex composition of the formulations. Here, we employ nano-thermal analysis (nanoTA) to probe the nanothermal domain of a pharmaceutical aerosol formulation containing a mixture of fluticasone propionate (FP), salmeterol xinafoate (SX), and excipient lactose, which is widely used to treat asthma and chronic obstructive pulmonary disease (COPD). Furthermore, atomic force microscopy-infrared spectroscopy (AFM-IR) and AFM force measurements are performed to provide nanochemical and nanomechanical information to complement the nanothermal data. The colocalized thermal and chemical mapping clearly reveals the surface heterogeneity of the drugs in the aerosol particles and demonstrates the contribution of the surface chemical composition to the variation in the thermal properties of the particles. We present a powerful analytical approach for in-depth characterization of thermal/chemical/morphological properties of dry powder inhaler particles at micro- and nanometer scales. This approach can be used to facilitate the comparison between generics and reference inhalation products and further the development of high-performance pharmaceutical formulations.
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页数:10
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