Prognostic significance of LAT1 expression in pleural mesothelioma

被引:0
作者
Taguchi, Ryo [1 ]
Kaira, Kyoichi [2 ]
Miura, Yu [2 ]
Umesaki, Tetsuya [1 ]
Mouri, Atsuto [2 ]
Imai, Hisao [2 ]
Kagamu, Hiroshi [2 ]
Yasuda, Masanori [3 ]
Kanai, Yoshikatsu [4 ,5 ,6 ]
Nitanda, Hiroyuki [1 ]
Ishida, Hironori [1 ]
Sakaguchi, Hirozo [1 ]
机构
[1] Dept Thorac Surg, Tottori, Japan
[2] Dept Resp Med, Hamamatsu, Japan
[3] Saitama Med Univ, Int Med Ctr, Dept Pathol, 1397-1 Yamane, Hidaka City 3501298, Japan
[4] Grad Sch Med, Dept Biosyst Pharmacol, Tokyo, Japan
[5] Premium Res Inst Human Metaverse Med WPI PRIMe, Osaka 5650871, Japan
[6] Osaka Univ, Inst Open & Transdisciplinary Res Initiat OTRI, Integrated Frontier Res Med Sci Div, Osaka, Japan
关键词
Malignant mesothelioma; LAT1; Prognosis; Immunohistochemistry; Predictive marker; ACID TRANSPORTER 1; ASCT2; MTOR;
D O I
10.1016/j.heliyon.2024.e37414
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: The L-type amino acid transporter (LAT1) exhibits significantly increased expression within tumor cells across various neoplasms. However, the clinical significance of LAT1 expression in patients with pleural mesothelioma (PM) remains unclear. Methods: Eighty patients diagnosed with PM between June 2007 and August 2022, were eligible for this study. LAT1, alanine-serine-cysteine transporter 2 (ASCT2), Ki-67, and VEGFR2 were evaluated by immunohistochemistry. Inflammatory and nutritional indices were also correlated with different variables, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic immune-inflammation index (SII), prognostic nutritional index (PNI), advanced lung cancer inflammation index (ALI), and Glasgow prognostic score (GPS). Results: LAT1 was highly expressed in 57.5 % of patients with PM. Among the 80 patients included in this study, 65 (81.3 %) received chemotherapy, either alone or followed by surgical resection, while 15 (18.7 %) opted for best supportive care. The level of LAT1 significantly correlated with cell proliferation and ASCT2. Factors such as performance status, histology, LAT1 expression, PNI, ALI, and GPS were significant prognostic indicators for progression-free survival (PFS), while Ki-67, LAT1, NLR, SII, PNI, ALI, and GPS were identified as significant predictors for overall survival (OS). LAT1 expression emerged as an independent prognostic factor for predicting PFS and OS in all patients, as well as in the subgroup of 65 patients receiving chemotherapy. Notably, high LAT1 expression proved to be a significant predictor of outcome, particularly in the subgroup with high PLR and SII. Conclusion: LAT1 was a significant predictor of outcomes in patients with PM and was more predictive of worse outcomes in patients with high inflammatory and low nutritional status.
引用
收藏
页数:10
相关论文
共 50 条
[41]   A comparison of epidermal growth factor receptor expression in malignant peritoneal and pleural mesothelioma [J].
Enomoto, Yasunori ;
Kasai, Takahiko ;
Takeda, Maiko ;
Takano, Masato ;
Morita, Kouhei ;
Kadota, Eiji ;
Iizuka, Norishige ;
Maruyama, Hiroshi ;
Haratake, Joji ;
Kojima, Yu ;
Ikeda, Naoya ;
Nonomura, Akitaka .
PATHOLOGY INTERNATIONAL, 2012, 62 (04) :226-231
[42]   L-Type Amino Acid Transporter 1 (LAT1) Expression in Canine Mammary Gland Tumors [J].
Fukumoto, Shinya ;
Hanazono, Kiwamu ;
Komatsu, Takahiro ;
Iwano, Hidetomo ;
Kadosawa, Tsuyoshi ;
Uchide, Tsuyoshi .
JOURNAL OF VETERINARY MEDICAL SCIENCE, 2013, 75 (04) :431-437
[43]   Gene Expression Analysis of Biphasic Pleural Mesothelioma: New Potential Diagnostic and Prognostic Markers [J].
Bruno, Rossella ;
Poma, Anello Marcello ;
Ali, Greta ;
Distefano, Claudia ;
Proietti, Agnese ;
Chella, Antonio ;
Lucchi, Marco ;
Melfi, Franca ;
Franco, Renato ;
Fontanini, Gabriella .
DIAGNOSTICS, 2022, 12 (03)
[44]   Nuclear grading, BAP1, mesothelin and PD-L1 expression in malignant pleural mesothelioma: prognostic implications [J].
Forest, Fabien ;
Patoir, Arnaud ;
Dal Col, Pierre ;
Sulaiman, Abdulrazzaq ;
Camy, Florian ;
Laville, David ;
Bayle-Bleuez, Sophie ;
Fournel, Pierre ;
Habougit, Cyril .
PATHOLOGY, 2018, 50 (06) :635-641
[45]   Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma: an international multicenter study [J].
Brcic, Luka ;
Klikovits, Thomas ;
Megyesfalvi, Zsolt ;
Mosleh, Berta ;
Sinn, Katharina ;
Hritcu, Richard ;
Laszlo, Viktoria ;
Cufer, Tanja ;
Rozman, Ales ;
Kern, Izidor ;
Mohorcic, Katja ;
Jakopovic, Marko ;
Samarzija, Miroslav ;
Seiwerth, Sven ;
Kolek, Vitezslav ;
Fischer, Ondrej ;
Jakubec, Petr ;
Skarda, Jozef ;
Gieszer, Balazs ;
Hegedus, Balazs ;
Fillinger, Janos ;
Renyi-Vamos, Ferenc ;
Buder, Anna ;
Bilecz, Agnes ;
Berger, Walter ;
Grusch, Michael ;
Hoetzenecker, Konrad ;
Klepetko, Walter ;
Hoda, Mir Alireza ;
Filipits, Martin ;
Dome, Balazs .
TRANSLATIONAL LUNG CANCER RESEARCH, 2021, 10 (04) :1594-1607
[46]   Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma [J].
Bilecz, Agnes ;
Stockhammer, Paul ;
Theegarten, Dirk ;
Kern, Izidor ;
Jakopovic, Marko ;
Samarzija, Miroslav ;
Klikovits, Thomas ;
Hoda, Mir A. ;
Dome, Balazs ;
Oberndorfer, Felicitas ;
Muellauer, Leonhard ;
Fillinger, Janos ;
Kovacs, Ildiko ;
Pirker, Christine ;
Schuler, Martin ;
Ploenes, Till ;
Aigner, Clemens ;
Klepetko, Walter ;
Berger, Walter ;
Brcic, Luka ;
Laszlo, Viktoria ;
Hegedus, Balazs .
HISTOPATHOLOGY, 2020, 77 (01) :55-66
[47]   Prognostic significance of neutrophil-to-lymphocyte ratio in patients with malignant pleural mesothelioma: a meta-analysis [J].
Chen, Nan ;
Liu, Shuai ;
Huang, Lin ;
Li, Wanling ;
Yang, Wenhao ;
Cong, Tianxin ;
Ding, Lin ;
Qiu, Meng .
ONCOTARGET, 2017, 8 (34) :57460-57469
[48]   Clinical significance of histologic subtyping of malignant pleural mesothelioma [J].
Brcic, Luka ;
Kern, Izidor .
TRANSLATIONAL LUNG CANCER RESEARCH, 2020, 9 (03) :924-933
[49]   Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma [J].
Ohta, Y ;
Shridhar, V ;
Kalemkerian, GP ;
Bright, RK ;
Watanabe, Y ;
Pass, HI .
CANCER, 1999, 85 (12) :2570-2576
[50]   Prognostic Biomarkers for Malignant Pleural Mesothelioma Treated with Chemotherapy [J].
Akgun, Hakan ;
Metintas, Selma ;
Ak, Guntulu ;
Demirkol, Secil ;
Aydin, Resat ;
Isbilen, Murat ;
Gure, Ali ;
Metintas, Muzaffer .
JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) :S1369-S1369