Clinical practice in European centres treating paediatric posterior fossa tumours with pencil beam scanning proton therapy

被引：2

作者：

Toussaint, Laura ^{[1
,2
]}

Matysiak, Witold ^{[3
]}

Alapetite, Claire ^{[4
]}

Aristu, Javier ^{[5
]}

Bannink-Gawryszuk, Agata ^{[3
]}

Bolle, Stephanie ^{[4
,6
,7
]}

Bolsi, Alessandra ^{[8
]}

Calvo, Felipe ^{[5
]}

Campoo, Fernando Cerron ^{[7
]}

Charlwood, Frances ^{[9
]}

Demoor-Goldschmidt, Charlotte ^{[10
,11
]}

Doyen, Jerome ^{[12
]}

Drosik-Rutowicz, Katarzyna ^{[13
]}

Dutheil, Pauline ^{[10
]}

Embring, Anna ^{[14
]}

Engellau, Jacob ^{[15
]}

Goedgebeur, Anneleen ^{[16
]}

Goudjil, Farid ^{[4
]}

Harrabi, Semi ^{[17
]}

Kopec, Renata ^{[18
]}

Kristensen, Ingrid ^{[15
]}

Laegsdmand, Peter ^{[1
,2
]}

Luetgendorf-Caucig, Carola ^{[19
]}

Meijers, Arturs ^{[8
]}

Mirandola, Alfredo ^{[20
]}

Missohou, Fernand ^{[10
]}

Feijoo, Marta Montero ^{[7
]}

Muren, Ludvig P. ^{[1
,2
]}

Ondrova, Barbora ^{[22
]}

Orlandi, Ester ^{[20
,21
]}

Pettersson, Erik ^{[23
,24
]}

Pica, Alessia ^{[8
]}

Plaude, Sandija ^{[25
]}

Righetto, Roberto ^{[26
]}

Rombi, Barbara ^{[27
]}

Timmermann, Beate ^{[25
,28
,29
]}

Van Beek, Karen ^{[16
]}

Vela, Anthony ^{[10
]}

Vennarini, Sabina ^{[30
]}

Vestergaard, Anne ^{[1
]}

Vidal, Marie ^{[12
]}

Vondracek, Vladimir ^{[22
]}

Weber, Damien C. ^{[8
]}

Whitfield, Gillian ^{[9
,31
]}

Zimmerman, Jens ^{[32
]}

Maduro, John H. ^{[3
]}

Lassen-Ramshad, Yasmin ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Danish Ctr Particle Therapy, Aarhus, Denmark

[2] Aarhus Univ, Dept Clin Med, Aarhus, Denmark

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, Groningen, Netherlands

[4] Inst Curie, Dept Radiat Oncol & Proton Ctr, Paris, France

[5] Clin Univ Navarra, Proton Therapy Unit, Madrid, Spain

[6] Inst Gustave Roussy, Dept Radiat Oncol, Villejuif, France

[7] Ctr Protonterapia Quironsalud, Madrid, Spain

[8] ETH Domain, Paul Scherrer Inst, Ctr Proton Therapy, Villigen, Switzerland

[9] Univ Manchester, Manchester Acad Hlth Sci Ctr, Christie NHS Fdn Trust, Manchester, England

[10] Ctr Reg Francois Baclesse, Dept Radiat Oncol, Caen, France

[11] Angers Univ Hosp, Dept Paediat Oncol, Angers, France

[12] Ctr Antoine Lacassagne, Dept Radiat Oncol, Nice, France

[13] Natl Res Inst Oncol Krakow, Dept Radiat Oncol, Gliwice branch, Krakow, Poland

[14] Karolinska Univ Hosp, Dept Radiotherapy, Stockholm, Sweden

[15] Skane Univ Hosp, Hematol Oncol & Radiat Phys, Lund, Sweden

[16] Univ Hosp Leuven, Dept Radiat Oncol, PARTICLE Proton Therapy Ctr, Leuven, Belgium

[17] Univ Hosp Heidelberg, Heidelberg Ion Beam Therapy Ctr, Dept Radiat Oncol, Heidelberg, Germany

[18] Polish Acad Sci, Inst Nucl Phys, Krakow, Poland

[19] MedAustron Ion Therapy Ctr, Dept Radiat Oncol, Wiener Neustadt, Austria

[20] Natl Ctr Oncol Hadrontherapy CNAO, Clin Dept, Radiat Oncol Unit, Pavia, Italy

[21] Univ Pavia, Dept Clin Surg Diag & Pediat Sci, Pavia, Italy

[22] Proton Therapy Ctr Czech, Dept Radiat Oncol, Prague, Czech Republic

[23] Sahlgrens Univ Hosp, Dept Therapeut Radiat Phys, Med Phys & Biomed Engn, Gothenburg, Sweden

[24] Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Med Radiat Sci, Gothenburg, Sweden

[25] Essen Univ Hosp, West German Proton Therapy Ctr Essen WPE, Essen, Germany

[26] Hosp S Chiara, APSS, Med Phys Unit, Trento, Italy

[27] APSS Trento, Trento Proton Therapy Ctr, Dept Radiat Oncol, Trento, Italy

[28] Univ Hosp Essen, Dept Particle Therapy, Essen, Germany

[29] German Canc Consortium DKTK, West German Canc Ctr WTZ, Essen, Germany

[30] IRCCS Fdn Inst Canc, Paediat Radiotherapy Unit, Milan, Italy

[31] Univ Manchester, Royal Manchester Childrens Hosp, Childrens Brain Tumour Res Network, Manchester, England

[32] Karolinska Univ Hosp, Dept Radiotherapy Phys & Engn, Stockholm, Sweden

来源：

RADIOTHERAPY AND ONCOLOGY | 2024年 / 198卷

关键词：

LINEAR-ENERGY-TRANSFER; BRAIN-STEM; RADIATION-THERAPY; CRANIOSPINAL IRRADIATION; PARAMETERS; CHILDREN;

D O I：

10.1016/j.radonc.2024.110414

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: As no guidelines for pencil beam scanning (PBS) proton therapy (PT) of paediatric posterior fossa (PF) tumours exist to date, this study investigated planning techniques across European PT centres, with special considerations for brainstem and spinal cord sparing. Materials and methods: A survey and a treatment planning comparison were initiated across nineteen European PBS-PT centres treating paediatric patients. The survey assessed all aspects of the treatment chain, including but not limited to delineations, dose constraints and treatment planning. Each centre planned two PF tumour cases for focal irradiation, according to their own clinical practice but based on common delineations. The prescription dose was 54 Gy(RBE) for Case 1 and 59.4 Gy (RBE) for Case 2. For both cases, planning strategies and relevant dose metrics were compared. Results: Seventeen (89 %) centres answered the survey, and sixteen (80 %) participated in the treatment planning comparison. In the survey, thirteen (68 %) centres reported using the European Particle Therapy Network definition for brainstem delineation. In the treatment planning study, while most centres used three beam directions, their configurations varied widely across centres. Large variations were also seen in brainstem doses, with a brainstem near maximum dose (D2%) ranging from 52.7 Gy(RBE) to 55.7 Gy(RBE) (Case 1), and from 56.8 Gy(RBE) to 60.9 Gy(RBE) (Case 2). Conclusion: This study assessed the European PBS-PT planning of paediatric PF tumours. Agreement was achieved in e.g. delineation-practice, while wider variations were observed in planning approach and consequently dose to organs at risk. Collaboration between centres is still ongoing, striving towards common guidelines.

引用

页数：8

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