A novel fluorescence enhancement Al(III) sensor based on C1 symmetric Binol imine derivative: Recognition, binding mechanism and Bio-imaging application

被引：0

作者：

Luo, Ru-yi ^{[1
]}

Wei, Zheng ^{[1
]}

Zhang, Wen-xiu ^{[1
]}

Qin, Dong-ji ^{[1
]}

Ning, Dong-yuan ^{[1
]}

Huang, Xiu-xiang ^{[1
]}

机构：

[1] Hechi Univ, Guangxi Coll Univ Key Lab Exploitat & Utilizat Mic, Sch Chem & Bioengn, Hechi 546300, Guangxi, Peoples R China

来源：

INORGANICA CHIMICA ACTA | 2024年 / 571卷

关键词：

Binol; Schiff base; Aluminum ion; Sensor; Fluorescence; TURN-ON SENSOR; SCHIFF-BASE; SELECTIVE RECOGNITION; AL3+; CHEMOSENSOR; ALUMINUM; PROBE; FE(III); IONS; ZN2+;

D O I：

10.1016/j.ica.2024.122230

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel C1 symmetric Binol imine Schiff base fluorescence sensor (Sa,R)-6 was designed and synthesized by using (S)-Binol-3-aldehyde as initial material. The probe showed great fluorescence enhancement at lambda = 552 nm and visual light yellow fluorescence under 365 nm UV lamp irradiation with presence of Al3+. Quantitative test was feasible from 10 mu M to the detection limit which reaches nanomole level. Job's plot, HRMS spectroscopic and NMR titration indicated the formation of Al[(Sa,R)-6]2+. DFT calculations suggested the coordination reaction lead to a CHEF effect and the "turn-on" fluorescence response. Moreover, (Sa,R)-6 was well tolerable to human normal astrocyte cell line HA-1800 in cell viability test so that it could be utilized for detecting trace Al3+ in vitro in a concentration-dependent manner via confocal imaging which proved its potential of diagnosis and treatment of Aluminum related diseases.

引用

页数：7