Single-cell sequencing has revealed a more complex array of thymic epithelial cells

被引：0

作者：

Pardini, Eleonora ^{[1
]}

Barachini, Serena ^{[2
]}

Ali, Greta ^{[3
]}

Infirri, Gisella Sardo ^{[1
]}

Burzi, Irene Sofia ^{[1
]}

Montali, Marina ^{[2
]}

Petrini, Iacopo ^{[1
]}

机构：

[1] Univ Pisa, Dept Translat Res & New Surg & Med Technol, Pisa, Italy

[2] Univ Pisa, Dept Clin & Expt Med, Via Roma 57, I-56126 Pisa, Italy

[3] Dept Surg Med & Mol Pathol & Crit Care Med, Pisa, Italy

来源：

IMMUNOLOGY LETTERS | 2024年 / 269卷

关键词：

Thymus; Thymic epithelial tumors; Medullary thymic epithelial cells; AIRE; Cortical thymic epithelial cells; PROMISCUOUS GENE-EXPRESSION; SELF-ANTIGEN EXPRESSION; NURSE CELLS; NEGATIVE SELECTION; POSITIVE SELECTION; STEM-CELLS; MEDULLARY; THYMOCYTES; PROGENITOR; DIFFERENTIATION;

D O I：

10.1016/j.imlet.2024.106904

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thymic epithelial cells participate in the maturation and selection of T lymphocytes. This review explores recent insights from single-cell sequencing regarding classifying thymic epithelial cells in both normal and neoplastic thymus. Cortical thymic epithelial cells facilitate thymocyte differentiation and contribute to positive selection. Medullary epithelial cells are distinguished by their expression of AIRE. Cells progress from a pre-AIRE state, containing precursors with cortical and medullary characteristics, termed junctional cells. Mature medullary epithelial cells exhibit promiscuous gene expression and after that downregulate AIRE mRNA. Post-AIRE cells can adopt a Hassall corpuscle-like phenotype or exhibit distinctive differentiation characteristics including tuft cells, ionocytes, neuroendocrine cells, and myoid cells.

引用

页数：10

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