Clinical efficacy and safety of faecal microbiota transplantation in the treatment of irritable bowel syndrome: a systematic review, meta-analysis and trial sequential analysis

被引：3

作者：

Lo, Shao-Wei ^{[1
]}

Hung, Tsung-Hsuan ^{[1
]}

Lin, Yen-Tsen ^{[1
]}

Lee, Chun-Shen ^{[1
]}

Chen, Chiung-Yu ^{[1
,2
]}

Fang, Ching-Ju ^{[3
,4
]}

Lai, Pei-Chun ^{[1
,5
]}

机构：

[1] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Educ Ctr, 138 Sheng Li Rd 704, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan, Taiwan

[3] Natl Cheng Kung Univ, Med Lib, Tainan, Taiwan

[4] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Secretariat, Tainan, Taiwan

[5] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Paediat, Tainan, Taiwan

来源：

EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2024年 / 29卷 / 01期

关键词：

Irritable bowel syndrome; Faecal microbiota transplantation; Systemic review; Meta-analysis; Randomised controlled trial; CLOSTRIDIUM-DIFFICILE-INFECTION; GUT MICROBIOME; DOUBLE-BLIND; RECURRENT; PLACEBO;

D O I：

10.1186/s40001-024-02046-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

BackgroundThe aim of this study is to evaluate the efficacy and safety of faecal microbiota transplantation (FMT) for the treatment of irritable bowel syndrome (IBS).MethodsWe searched four databases for randomised controlled trials (RCTs) that compared FMT with a control intervention in patients with IBS. The revised Cochrane risk-of-bias (RoB) tool was chosen for appraisal. Meta-analysis with trial sequential analysis (TSA) was conducted. Grading of Recommendations Assessment Development and Evaluation (GRADE) methodology was used to assess the certainty of evidence (CoE).ResultsWe included 12 RCTs with a total of 615 participants. Meta-analyses showed no significant difference between the FMT and control groups in terms of clinical responses (relative risk [RR] = 1.44, 95% confidence interval [CI] 0.88-2.33) and changes in IBS Severity Scoring System (IBS-SSS) scores (standardised mean difference [SMD] = - 0.31, 95% CI - 0.72 to 0.09) and IBS Quality of Life (IBS-QOL) scores (SMD = 0.30, 95% CI - 0.09 to 0.69). Subgroup analysis revealed that in studies with low RoB and using endoscopy, nasojejunal tube and rectal enema delivery, FMT led to a significant improvement in clinical responses and changes in IBS-SSS and IBS-QOL scores. TSA suggested that the current evidence is inconclusive and that the CoE is very low.ConclusionThis study suggests that patients with IBS may benefit from FMT especially when it is administered via endoscopy, nasojejunal tube or rectal enema. However, the certainty of evidence is very low. Further research is needed to confirm the efficacy and safety of FMT for IBS treatment.Trial Registration: PROSPERO registration number CRD42020211002.ConclusionThis study suggests that patients with IBS may benefit from FMT especially when it is administered via endoscopy, nasojejunal tube or rectal enema. However, the certainty of evidence is very low. Further research is needed to confirm the efficacy and safety of FMT for IBS treatment.Trial Registration: PROSPERO registration number CRD42020211002.

引用

页数：15

共 55 条

[1] Efficacy and safety of fecal microbiota transplant in irritable bowel syndrome: An update based on meta-analysis of randomized control trials [J].