Antidiabetic drugs in Parkinson's disease

被引：4
作者：
Aguirre-Vidal, Yoshajandith [1 ]
Montes, Sergio [2 ]
Mota-Lopez, Ana Carolina [1 ]
Navarrete-Vazquez, Gabriel [3 ]
机构：
[1] Inst Ecol AC INECOL, Red Estudios Mol Avanzados, Campus 3, Xalapa 91073, Veracruz, Mexico
[2] Unidad Acad Multidisciplinaria, Reynosa 88740, Tamaulipas, Mexico
[3] Univ Autonoma Estado Morelos, Fac Farm, Cuernavaca 62209, Morelos, Mexico
来源：
CLINICAL PARKINSONISM & RELATED DISORDERS | 2024年 / 11卷
关键词：
Parkinson's disease; Type; 2; diabetes; Hyperglycemia; Drug repositioning; ACTIVATED-RECEPTOR-GAMMA; MPTP MOUSE MODEL; NF-KAPPA-B; SUBSTANTIA-NIGRA; MOTOR DEFICITS; RAT MODEL; INSULIN; PIOGLITAZONE; LIRAGLUTIDE; AGONIST;
D O I：
10.1016/j.prdoa.2024.100265
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This review explores the intricate connections between type 2 diabetes (T2D) and Parkinson's disease (PD), both prevalent chronic conditions that primarily affect the aging population. These diseases share common early biochemical pathways that contribute to tissue damage. This manuscript also systematically compiles potential shared cellular mechanisms between T2D and PD and discusses the literature on the utilization of antidiabetic drugs as potential therapeutic options for PD. This review encompasses studies investigating the experimental and clinical efficacy of antidiabetic drugs in the treatment of Parkinson's disease, along with the proposed mechanisms of action. The exploration of the benefits of antidiabetic drugs in PD presents a promising avenue for the treatment of this neurodegenerative disorder.
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页数：8
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