Succinate Dehydrogenase and Human Disease: Novel Insights into a Well-Known Enzyme

被引：4
作者：
Esteban-Amo, Maria J. [1 ,2 ,3 ]
Jimenez-Cuadrado, Patricia [1 ,2 ,3 ]
Serrano-Lorenzo, Pablo [4 ,5 ]
de la Fuente, Miguel a. [1 ,2 ,3 ]
Simarro, Maria [1 ,2 ,3 ]
机构：
[1] Univ Valladolid, Fac Med, Dept Cell Biol Genet Histol & Pharmacol, Valladolid 47005, Spain
[2] Univ Valladolid, Unit Excellence Inst Biomed & Mol Genet IBGM, Valladolid 47003, Spain
[3] CSIC, Valladolid 47003, Spain
[4] Hosp 12 Octubre Res Inst, Clin Biochem Dept, Mitochondrial Disorders Lab, imas12, Madrid 28041, Spain
[5] Inst Salud Carlos III, Biomed Network Res Ctr Rare Dis CIBERER, Madrid 28029, Spain
来源：
BIOMEDICINES | 2024年 / 12卷 / 09期
关键词：
mitochondria; succinate dehydrogenase; complex II; disease; MITOCHONDRIAL COMPLEX II; ELECTRON-TRANSPORT CHAIN; SDH-DEFICIENT CELLS; REDUCTIVE CARBOXYLATION; GLUTAMINE-METABOLISM; FUNCTIONAL EXPRESSION; MUTATIONS; HYPERMETHYLATION; GLYCOLYSIS; GENERATION;
D O I：
10.3390/biomedicines12092050
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Succinate dehydrogenase (also known as complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the tricarboxylic acid (TCA) cycle and transferring electrons from succinate to ubiquinone in the mitochondrial electron transport chain (ETC). Owing to the privileged position of SDH/CII, its dysfunction leads to TCA cycle arrest and altered respiration. This review aims to elucidate the widely documented profound metabolic effects of SDH/CII deficiency, along with the newly unveiled survival mechanisms in SDH/CII-deficient cells. Such an understanding reveals exploitable vulnerabilities for strategic targeting, which is crucial for the development of novel and more precise therapies for primary mitochondrial diseases, as well as for familial and sporadic cancers associated with SDH/CII mutations.
引用
收藏
页数：14
相关论文
共 64 条
  • [1] Succinate Dehydrogenase Complex An Updated Review
    Al Rasheed, Mohamed Rizwan Haroon
    Tarjan, Gabor
    [J]. ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2018, 142 (12) : 1564 - 1570
  • [2] Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency
    Alston, Charlotte L.
    Davison, James E.
    Meloni, Francesca
    van der Westhuizen, Francois H.
    He, Langping
    Hue-Tran Hornig-Do
    Peet, Andrew C.
    Gissen, Paul
    Goffrini, Paola
    Ferrero, Ileana
    Wassmer, Evangeline
    McFarland, Robert
    Taylor, Robert W.
    [J]. JOURNAL OF MEDICAL GENETICS, 2012, 49 (09) : 569 - 577
  • [3] Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells
    Altea-Manzano, Patricia
    Vandekeere, Anke
    Edwards-Hicks, Joy
    Roldan, Mar
    Abraham, Emily
    Lleshi, Xhordi
    Guerrieri, Ania Naila
    Berardi, Domenica
    Wills, Jimi
    Junior, Jair Marques
    Pantazi, Asimina
    Acosta, Juan Carlos
    Sanchez-Martin, Rosario M.
    Fendt, Sarah-Maria
    Martin-Hernandez, Miguel
    Finch, Andrew J.
    [J]. MOLECULAR CELL, 2022, 82 (23) : 4537 - +
  • [4] From Krebs to clinic: glutamine metabolism to cancer therapy
    Altman, Brian J.
    Stine, Zachary E.
    Dang, Chi V.
    [J]. NATURE REVIEWS CANCER, 2016, 16 (10) : 619 - 634
  • [5] Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog
    Bandara, Aloka B.
    Drake, Joshua C.
    Brown, David A.
    [J]. BMC MOLECULAR AND CELL BIOLOGY, 2021, 22 (01)
  • [6] Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints
    Bezawork-Geleta, Ayenachew
    Wen, He
    Dong, LanFeng
    Yan, Bing
    Vider, Jelena
    Boukalova, Stepana
    Krobova, Linda
    Vanova, Katerina
    Zobalova, Renata
    Sobol, Margarita
    Hozak, Pavel
    Novais, Silvia Magalhaes
    Caisova, Veronika
    Abaffy, Pavel
    Naraine, Ravindra
    Pang, Ying
    Zaw, Thiri
    Zhang, Ping
    Sindelka, Radek
    Kubista, Mikael
    Zuryn, Steven
    Molloy, Mark P.
    Berridge, Michael V.
    Pacak, Karel
    Rohlena, Jakub
    Park, Sunghyouk
    Neuzil, Jiri
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [7] Mitochondrial Complex II: At the Crossroads
    Bezawork-Geleta, Ayenachew
    Rohlena, Jakub
    Dong, Lanfeng
    Pacak, Karel
    Neuzil, Jiri
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2017, 42 (04) : 312 - 325
  • [8] An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
    Birsoy, Kivanc
    Wang, Tim
    Chen, Walter W.
    Freinkman, Elizaveta
    Abu-Remaileh, Monther
    Sabatini, David M.
    [J]. CELL, 2015, 162 (03) : 540 - 551
  • [9] Manganese ions induce H2O2 generation at the ubiquinone binding site of mitochondrial complex II
    Bonke, Erik
    Zwicker, Klaus
    Droese, Stefan
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2015, 580 : 75 - 83
  • [10] The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway
    Borst, Piet
    [J]. IUBMB LIFE, 2020, 72 (11) : 2241 - 2259
1234567