In vivo absorption, in vitro simulated digestion, and fecal fermentation properties of Imperata cylindrica polysaccharides and their effects on gut microbiota

被引：8

作者：

Yu, Wenchen ^{[1
,2
,3
,4
]}

Wang, Junwen ^{[2
,3
,4
]}

Xiong, Yi ^{[1
,2
,3
,4
]}

Liu, Jiaren ^{[3
]}

Baranenko, Denis ^{[6
]}

Zhang, Yingchun ^{[2
,3
,4
,5
]}

Lu, Weihong ^{[2
,3
,4
,5
]}

机构：

[1] Harbin Inst Technol, Sch Chem & Chem Engn, Harbin, Peoples R China

[2] Harbin Inst Technol, Natl & Local Joint Engn Lab Synth, Harbin, Peoples R China

[3] Harbin Inst Technol, Sch Med & Hlth, Harbin, Peoples R China

[4] Harbin Inst Technol, Chongqing Res Inst, Chongqing, Peoples R China

[5] Harbin Inst Technol, Zhengzhou Res Inst, Zhengzhou, Peoples R China

[6] ITMO Univ, Fac Ecotechnol, Sch Life Sci, St Petersburg 197101, Russia

来源：

FOOD CHEMISTRY | 2024年 / 461卷

关键词：

Imperata cylindrica; Polysaccharide; Digestion; Fermentation; Gut microbiota; PHARMACOKINETICS; SALIVA;

D O I：

10.1016/j.foodchem.2024.140773

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Recently we have investigated polysaccharide from Imperata cylindrica (ICP) for its physicochemical structure and biological activities. However, the digestion characteristics have yet to be understood. This study investigated the digestion and metabolism characteristics of ICP through in vivo fluorescence tracking, in vitro simulated digestion, fecal fermentation experiments, and microbial sequencing. The results showed that ICP significant distribution in the gastrointestinal tract and kidneys. ICP underwent slight degradation during simulated gastric and intestinal digestion. During fecal fermentation, the utilization degree of ICP and the concentration of shortchain fatty acids (SCFAs) increased. ICP promoted the increase of beneficial microbial abundance. To understand the impact of ICP on the integrity and health of intestinal tissues, molecular docking was employed to preliminarily predict the interaction between ICP and key proteins. The results revealed that ICP could recognize and bind to key proteins through high-affinity targeting binding sites.

引用

页数：14

共 47 条

[1] Gene Ontology: tool for the unification of biology [J].

Ashburner, M ;

Ball, CA ;

Blake, JA ;

Botstein, D ;

Butler, H ;

Cherry, JM ;

Davis, AP ;

Dolinski, K ;

Dwight, SS ;

Eppig, JT ;

Harris, MA ;

Hill, DP ;

Issel-Tarver, L ;

Kasarskis, A ;

Lewis, S ;

Matese, JC ;

Richardson, JE ;

Ringwald, M ;

Rubin, GM ;

Sherlock, G .

NATURE GENETICS, 2000, 25 (01) :25-29

[2] Systematic assessment of oat fi -glucan catabolism during in vitro digestion and fermentation [J].

Bai, Junying ;

Li, Tingting ;

Zhang, Wenhui ;

Fan, Mingcong ;

Qian, Haifeng ;

Li, Yan ;

Wang, Li .

FOOD CHEMISTRY, 2021, 348

[3] Study on pharmacokinetics and tissue distribution of Polygonatum sibiricum polysaccharide in rats by fluorescence labeling [J].

Bi, Jianli ;

Zhao, Chujin ;

Jin, Wenfang ;

Chen, Qingjie ;

Fan, Baolei ;

Qian, Chunqi .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 215 :541-549

[4] Digestion under saliva, simulated gastric and small intestinal conditions and fermentation in vitro by human intestinal microbiota of polysaccharides from Fuzhuan brick tea [J].

Chen, Guijie ;

Xie, Minhao ;

Wan, Peng ;

Chen, Dan ;

Ye, Hong ;

Chen, Ligen ;

Zeng, Xiaoxiong ;

Liu, Zhonghua .

FOOD CHEMISTRY, 2018, 244 :331-339

[5] The role of short-chain fatty acids in microbiota-gut-brain communication [J].

Dalile, Boushra ;

Van Oudenhove, Lukas ;

Vervliet, Bram ;

Verbeke, Kristin .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2019, 16 (08) :461-478

[6] In vitro and in vivo gastrointestinal digestion and fermentation of the polysaccharide from Ganoderma atrum [J].

Ding, Qiao ;

Nie, Shaoping ;

Hu, Jielun ;

Zong, Xinyan ;

Li, Qiqiong ;

Xie, Mingyong .

FOOD HYDROCOLLOIDS, 2017, 63 :646-655

[7] Gut microbiota regulation and prebiotic properties of polysaccharides from Oudemansiella raphanipes mushroom [J].

Fang, Qi ;

Lai, Yong ;

Zhang, Dan ;

Lei, Hui ;

Wang, Fang ;

Guo, Xiurong ;

Song, Can .

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2023, 39 (07)

[8] The role of the gut microbiota in nutrition and health [J].

Flint, Harry J. ;

Scott, Karen P. ;

Louis, Petra ;

Duncan, Sylvia H. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2012, 9 (10) :577-589

[9] Environmental factors shaping the gut microbiome in a Dutch population [J].

Gacesa, R. ;

Kurilshikov, A. ;

Vich Vila, A. ;

Sinha, T. ;

Klaassen, M. A. Y. ;

Bolte, L. A. ;

Andreu-Sanchez, S. ;

Chen, L. ;

Collij, V. ;

Hu, S. ;

Dekens, J. A. M. ;

Lenters, V. C. ;

Bjork, J. R. ;

Swarte, J. C. ;

Swertz, M. A. ;

Jansen, B. H. ;

Gelderloos-Arends, J. ;

Jankipersadsing, S. ;

Hofker, M. ;

Vermeulen, R. C. H. ;

Sanna, S. ;

Harmsen, H. J. M. ;

Wijmenga, C. ;

Fu, J. ;

Zhernakova, A. ;

Weersma, R. K. .

NATURE, 2022, 604 (7907) :732-+

[10] Effects of a homogeneous polysaccharide from Sijunzi decoction on human intestinal microbes and short chain fatty acids in vitro [J].

Gao, Beibei ;

Wang, Ruijun ;

Peng, Ying ;

Li, Xiaobo .

JOURNAL OF ETHNOPHARMACOLOGY, 2018, 224 :465-473

← 1 2 3 4 5 →