Iridium-catalyzed reduction of o-hydroxyl phenyl enaminones for the synthesis of propiophenones and their application in 3-methyl chromone synthesis

被引：1
作者：
Tu, Zhi [1 ]
Wan, Jie-Ping [1 ]
Wei, Li [1 ]
Liu, Yunyun [1 ]
机构：
[1] Jiangxi Normal Univ, Coll Chem & Mat, Nanchang 330022, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 41期
基金：
中国国家自然科学基金;
关键词：
SILANE-REDUCTION; FRIEDEL-CRAFTS; KETONES; HYDROGENATION; DERIVATIVES; ACETAL; DMF;
D O I：
10.1039/d4ob01359j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method of reducing o-hydroxyphenyl enaminones with silane as the reductant to provide o-hydroxyl propiophenones has been achieved with iridium catalysis. The reduction reactions were found to proceed via the assistance of the hydroxyl group in the phenyl ring. In addition, the o-hydroxyl propiophenone products were used for the easy synthesis of 3-methyl chromones by directly incorporating N,N-dimethyl formamide dimethyl acetal (DMF-DMA) without using any catalyst.
引用
收藏
页码：8279 / 8284
页数：6
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