A prospective multicenter observational study assessing incidence and risk factors for acute blood transfusion reactions in dogs

被引：2

作者：

Hall, Georgina B. F. ^{[1
]}

Birkbeck, Rachael ^{[2
]}

Brainard, Benjamin M. ^{[3
]}

Camacho, Fernanda ^{[4
]}

Davidow, Elizabeth B. ^{[5
]}

Levine, Dana N. ^{[6
]}

Mackin, Andrew ^{[7
]}

Moss, Taylor ^{[6
]}

Nash, Katherine J. ^{[8
]}

Stanzani, Giacomo ^{[9
]}

Starybrat, Daria ^{[10
]}

Stoye, David Q. ^{[11
]}

Tai, Carolyn ^{[12
]}

Thomason, John ^{[7
]}

Walker, Julie M. ^{[13
]}

Wardrop, K. Jane ^{[14
]}

Wilson, Helen ^{[15
]}

Wurlod, Virginie A. ^{[16
]}

Humm, Karen ^{[1
]}

机构：

[1] Royal Vet Coll, Clin Sci & Serv, London, England

[2] The Ralph, Marlow, England

[3] Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg, Athens, GA USA

[4] Willows Vet Ctr & Referral Serv, Solihull, England

[5] Timberline Vet Emergency & Specialty, Seattle, WA USA

[6] Auburn Univ, Dept Clin Sci, Coll Vet Med, Auburn, AL USA

[7] Mississippi State Univ, Coll Vet Med, Starkville, MS USA

[8] Univ Queensland, Sch Vet Sci, Gatton, Qld, Australia

[9] Dick White Referrals, Newmarket, England

[10] Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh, Scotland

[11] Oxford Sch Publ Hlth, Oxford, England

[12] Tufts Univ, Cummings Sch Vet Med, North Grafton, MA USA

[13] Univ Wisconsin, Madison Sch Vet Med, Dept Med Sci, Madison, WI USA

[14] Washington State Univ, Coll Vet Med, Pullman, WA USA

[15] Univ Bristol, Langford Vets, Bristol, England

[16] Louisiana State Univ, Sch Vet Med, Baton Rouge, LA USA

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 2024年 / 38卷 / 05期

关键词：

AHTR; dog; FNHTR; leukoreduction; storage lesion; TACO; TRALI; CELL TRANSFUSIONS; PLATELET CONCENTRATE; COMPLICATIONS; FEBRILE; AGE;

D O I：

10.1111/jvim.17175

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

BackgroundReported incidence of blood transfusion reactions (TR) varies greatly.ObjectiveTo prospectively evaluate the incidence of acute TRs in dogs receiving allogenic blood products, using consensus definitions, and to assess factors associated with TRs.AnimalsDogs (n = 858) administered allogenic blood products (n = 1542) between March and November 2022.MethodsProspective, multicenter surveillance study occurring in referral hospitals in the United States, United Kingdom, and Australia recording TRs in dogs administered blood products as defined by the consensus guidelines published by The Association of Veterinary Hematology and Transfusion Medicine in 2021.ResultsThe incidence of acute TR was 8.9% (95% CI 7.0-11.1) for packed red blood cells (pRBCs) and 4.5% (95% CI 2.9-6.6) for plasma products. The most frequently reported TRs were febrile nonhemolytic TRs (FNHTR; 4%, 95% CI 2.8-5.5) when administering pRBCs and allergic TRs (3.2%, 95% CI 1.80-5.10) when administering plasma products. A higher dose of pRBC (adjusted odds ratio [aOR] 1.04 [95% CI 1.00-1.08]) was associated with a higher odds of TR. Administration of pRBCs stored for longer than 28 days was associated with higher odds of FNHTR (aOR 4.10 [95% CI 1.58-10.65]) and acute hemolytic TR (AHTR; OR 15.2 [95% CI 3.35-68.70]) when compared with pRBCs stored for 14 days or fewer. Leukoreduction of pRBC was not associated with lower odds of developing a TR (OR 1.47 [95% CI 0.89-2.42]).Conclusions and Clinical ImportanceClinicians should be mindful of the age and dose of pRBC prescribed to dogs.

引用

页码：2495 / 2506

页数：12

共 34 条

[1] Effect of premedication and other factors on the occurrence of acute transfusion reactions in dogs [J].