Modelling radiobiology

被引：4

作者：

Gardner, Lydia L. ^{[1
]}

Thompson, Shannon J. ^{[1
]}

O'Connor, John D. ^{[1
,2
]}

Mcmahon, Stephen J. ^{[1
]}

机构：

[1] Queens Univ Belfast, Patrick G Johnston Ctr Canc Res, 97 Lisburn Rd, Belfast BT9 7AE, North Ireland

[2] Ulster Univ, Sch Engn, York St, Belfast BT15 1AP, North Ireland

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2024年 / 69卷 / 18期

关键词：

modelling; radiobiology; Monte Carlo; DNA repair; cell death; MONTE-CARLO-SIMULATION; TUMOR-CONTROL PROBABILITY; LINEAR-QUADRATIC MODEL; INDUCED DNA-DAMAGE; GENOME-WIDE ASSOCIATION; BASE EXCISION-REPAIR; RADIOSENSITIVITY INDEX PREDICTS; TRACK STRUCTURE CODE; DOUBLE-STRAND BREAKS; CANCER STEM-CELLS;

D O I：

10.1088/1361-6560/ad70f0

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Radiotherapy has played an essential role in cancer treatment for over a century, and remains one of the best-studied methods of cancer treatment. Because of its close links with the physical sciences, it has been the subject of extensive quantitative mathematical modelling, but a complete understanding of the mechanisms of radiotherapy has remained elusive. In part this is because of the complexity and range of scales involved in radiotherapy-from physical radiation interactions occurring over nanometres to evolution of patient responses over months and years. This review presents the current status and ongoing research in modelling radiotherapy responses across these scales, including basic physical mechanisms of DNA damage, the immediate biological responses this triggers, and genetic- and patient-level determinants of response. Finally, some of the major challenges in this field and potential avenues for future improvements are also discussed.

引用

页数：40

共 408 条

[1] Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer [J].

Abazeed, Mohamed E. ;

Adams, Drew J. ;

Hurov, Kristen E. ;

Tamayo, Pablo ;

Creighton, Chad J. ;

Sonkin, Dmitriy ;

Giacomelli, Andrew O. ;

Du, Charles ;

Fries, Daniel F. ;

Wong, Kwok-Kin ;

Mesirov, Jill P. ;

Loeffler, Jay S. ;

Schreiber, Stuart L. ;

Hammerman, Peter S. ;

Meyerson, Matthew .

CANCER RESEARCH, 2013, 73 (20) :6289-6298

[2] Coordination of DNA single strand break repair [J].

Abbotts, Rachel ;

Wilson, David M., III .

FREE RADICAL BIOLOGY AND MEDICINE, 2017, 107 :228-244

[3] Global Radiotherapy: Current Status and Future Directions-White Paper [J].

Abdel-Wahab, May ;

Gondhowiardjo, Soehartati S. ;

Rosa, Arthur Accioly ;

Lievens, Yolande ;

El-Haj, Noura ;

Rubio, Jose Alfredo Polo ;

Ben Prajogi, Gregorius ;

Helgadottir, Herdis ;

Zubizarreta, Eduardo ;

Meghzifene, Ahmed ;

Ashraf, Varisha ;

Hahn, Stephen ;

Williams, Tim ;

Gospodarowicz, Mary .

JCO GLOBAL ONCOLOGY, 2021, 7 :827-842

[4] GEANT4-a simulation toolkit [J].

Agostinelli, S ;

Allison, J ;

Amako, K ;

Apostolakis, J ;

Araujo, H ;

Arce, P ;

Asai, M ;

Axen, D ;

Banerjee, S ;

Barrand, G ;

Behner, F ;

Bellagamba, L ;

Boudreau, J ;

Broglia, L ;

Brunengo, A ;

Burkhardt, H ;

Chauvie, S ;

Chuma, J ;

Chytracek, R ;

Cooperman, G ;

Cosmo, G ;

Degtyarenko, P ;

Dell'Acqua, A ;

Depaola, G ;

Dietrich, D ;

Enami, R ;

Feliciello, A ;

Ferguson, C ;

Fesefeldt, H ;

Folger, G ;

Foppiano, F ;

Forti, A ;

Garelli, S ;

Giani, S ;

Giannitrapani, R ;

Gibin, D ;

Cadenas, JJG ;

González, I ;

Abril, GG ;

Greeniaus, G ;

Greiner, W ;

Grichine, V ;

Grossheim, A ;

Guatelli, S ;

Gumplinger, P ;

Hamatsu, R ;

Hashimoto, K ;

Hasui, H ;

Heikkinen, A ;

Howard, A .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2003, 506 (03) :250-303

[5] The radiosensitivity index predicts for overall survival in glioblastoma [J].

Ahmed, Kamran A. ;

Chinnaiyan, Prakash ;

Fulp, William J. ;

Eschrich, Steven ;

Torres-Roca, Javier F. ;

Caudell, Jimmy J. .

ONCOTARGET, 2015, 6 (33) :34414-34422

[6]

Allison J., 2016, Nucl. Instrum. Methods Phys. Res. A, V835, P186, DOI DOI 10.1016/J.NIMA.2016.06.125

[7] ROLE OF OXYGEN IN MODIFYING THE RADIOSENSITIVITY OF E-COLI-B [J].

ALPER, T ;

HOWARDFLANDERS, P .

NATURE, 1956, 178 (4540) :978-979

[8] Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen [J].

Amundson, Sally A. ;

Do, Khanh T. ;

Vinikoor, Lisa C. ;

Lee, R. Anthony ;

Koch-Paiz, Christine A. ;

Ahn, Jaeyong ;

Reimers, Mark ;

Chen, Yidong ;

Scudiero, Dominic A. ;

Weinstein, John N. ;

Trent, Jeffrey M. ;

Bittner, Michael L. ;

Meltzer, Paul S. ;

Fornace, Albert J., Jr. .

CANCER RESEARCH, 2008, 68 (02) :415-424

[9] Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients [J].

Andreassen, Christian Nicolaj ;

Rosenstein, Barry S. ;

Kerns, Sarah L. ;

Ostrer, Harry ;

De Ruysscher, Dirk ;

Cesaretti, Jamie A. ;

Barnett, Gillian C. ;

Dunning, Alison M. ;

Dorling, Leila ;

West, Catharine M. L. ;

Burnet, Neil G. ;

Elliott, Rebecca ;

Coles, Charlotte ;

Hall, Emma ;

Fachal, Laura ;

Vega, Ana ;

Gomez-Caamano, Antonio ;

Talbot, Christopher J. ;

Symonds, R. Paul ;

De Ruyck, Kim ;

Thierens, Hubert ;

Ost, Piet ;

Chang-Claude, Jenny ;

Seibold, Petra ;

Popanda, Odilia ;

Overgaard, Marie ;

Dearnaley, David ;

Sydes, Matthew R. ;

Azria, David ;

Koch, Christine Anne ;

Parliament, Matthew ;

Blackshaw, Michael ;

Sia, Michael ;

Fuentes-Raspall, Maria J. ;

Ramon y Cajal, Teresa ;

Barnadas, Agustin ;

Vesprini, Danny ;

Gutierrez-Enriquez, Sara ;

Molla, Meritxell ;

Diez, Orland ;

Yarnold, John R. ;

Overgaard, Jens ;

Bentzen, Soren M. ;

Alsner, Jan .

RADIOTHERAPY AND ONCOLOGY, 2016, 121 (03) :431-439

[10] Radiogenomics - current status, challenges and future directions [J].

Andreassen, Christian Nicolaj ;

Schack, Line Meinertz Hybel ;

Laursen, Louise Vagner ;

Alsner, Jan .

CANCER LETTERS, 2016, 382 (01) :127-136

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