Exploring the evolving roles and clinical significance of circRNAs in head and neck squamous cell carcinoma

被引：1

作者：

Lei, Pengxiang ^{[1
]}

Guo, Qingbo ^{[1
]}

Hao, Jiewen ^{[2
]}

Liu, Hui ^{[3
,4
]}

Chen, Yaofeng ^{[4
,5
]}

Wu, Feng ^{[6
]}

He, Zhao ^{[6
]}

Zhong, Xiaolong ^{[6
]}

Zhang, Nannan ^{[4
,5
]}

Wen, Shuxin ^{[2
]}

Gao, Wei ^{[7
,8
,9
]}

Wu, Yongyan ^{[1
,4
,7
,8
,9
,10
]}

机构：

[1] Shanxi Med Univ, Hosp 1, Dept Otolaryngol Head & Neck Surg, Shanxi Key Lab Otorhinolaryngol Head & Neck Canc, Taiyuan 030001, Shanxi, Peoples R China

[2] Third Hosp Shanxi Med Univ, Shanxi Bethune Hosp, Gen Surg Dept, Taiyuan 030032, Shanxi, Peoples R China

[3] Shenzhen Univ, Shenzhen Univ Gen Hosp, Dept Hepatobiliary Surg, Shenzhen 518055, Guangdong, Peoples R China

[4] Shenzhen Univ, Shenzhen Univ Clin Med Acad, Shenzhen 518055, Guangdong, Peoples R China

[5] Shenzhen Univ, Shenzhen Univ Gen Hosp, Dept Otolaryngol Head & Neck Surg, Shenzhen 518055, Guangdong, Peoples R China

[6] Northwest A&F Univ, Shenzhen Res Inst, Shenzhen 518000, Guangdong, Peoples R China

[7] Longgang Otolaryngol Hosp, Dept Otolaryngol Head & Neck Surg, Shenzhen 518172, Guangdong, Peoples R China

[8] Longgang Otolaryngol Hosp, Shenzhen Inst Otolaryngol, Shenzhen 518172, Guangdong, Peoples R China

[9] Longgang Otolaryngol Hosp, Key Lab Otolaryngol, Shenzhen 518172, Guangdong, Peoples R China

[10] Shenzhen Univ, Shenzhen Univ Gen Hosp, Shenzhen 518055, Guangdong, Peoples R China

来源：

JOURNAL OF CANCER | 2024年 / 15卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Head and neck squamous cell carcinoma; Circular RNA; Biomarker; Non-coding RNA; Immune evasion; Cancer stem cell; CIRCULAR RNA; NASOPHARYNGEAL CARCINOMA; PROMOTES PROLIFERATION; PROGRESSION; CANCER; BIOMARKER; METASTASIS; AUTOPHAGY; INVASION; AXIS;

D O I：

10.7150/jca.96614

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Head and neck squamous cell carcinoma (HNSCC) represents the predominant malignancies in the head and neck region, and has limited therapeutic alternatives. Circular RNAs (circRNAs), a substantial category of non-coding RNA molecules, exert influential roles in human disease development and progression, employing various mechanisms such as microRNA sponging, interaction with RNA-binding proteins, and translational capabilities. Accumulating evidence highlights the differential expression of numerous circRNAs in HNSCC, and numerous dysregulated circRNAs underscore their crucial involvement in malignant advancement and resistance to treatment. This review aims to comprehensively outline the characteristics, biogenesis, and mechanisms of circRNAs, elucidating their functional significance in HNSCC. In addition, we delve into the clinical implications of circRNAs, considering their potential as biomarkers or targets for diagnosis, prognosis, and therapeutic applications in HNSCC. The discussion extends to exploring future challenges in the clinical translation of circRNAs, emphasizing the need for further research.

引用

页码：3984 / 3994

页数：11

共 138 条

[1]

Bai J, 2022, PAIN PHYSICIAN, V25, pE1137

[2] Structure and function of p62/SQSTM1 in the emerging framework of phase separation [J].