Discovery of novel Quinazoline-based KRAS G12C inhibitors as potential anticancer agents (vol 71, 116962, 2022)

被引：0
|
作者：
Li, Ling [1 ,2 ]
Zhao, Huiting [2 ]
Peng, Xiaopeng [3 ]
Liu, Jin [2 ]
Mai, Ruiyao [2 ]
Chen, Jingxuan
Lin, Lin [4 ]
Chen, Ting [4 ]
Yan, Jun [5 ,6 ]
Shi, Jiaolong [5 ,6 ]
Chen, Jianjun [2 ,5 ,6 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 8, Shenzhen 518033, Peoples R China
[2] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China
[3] Gannan Med Univ, Coll Pharm, Ganzhou 314000, Peoples R China
[4] Southern Med Univ, Nanfang Hosp, Dept Stomatol, Guangzhou 510515, Peoples R China
[5] Southern Med Univ, Dept Gen Surg, Guangzhou 510515, Guangdong, Peoples R China
[6] Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestinal, Guangzhou 510515, Guangdong, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2024年 / 111卷
关键词：
D O I：
10.1016/j.bmc.2024.117840
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：1
相关论文
共 43 条
  • [31] Targeting adaptive resistance to EGFR and KRAS G12C inhibitors by TT125-802, a novel and specific CBP/p300 bromodomain inhibitor
    Bohnacker, Thomas
    Gruber, Dorothea
    Laudato, Sara
    Schwill, Martin
    Fabritius, Charles-Henry
    Herrador, Raquel
    Westritschnig, Katrin
    Pattupara, Thushara
    Ayinampudi, Vikram
    Fluckiger-Mangual, Stefanie
    CANCER RESEARCH, 2023, 83 (07)
  • [32] Safety assessment of KRAS (G12C) inhibitors based on the FDA Adverse Event Reporting System (FAERS) database: A real-world pharmacovigilance study
    Chen, Maohua
    Huang, Yaping
    Jiang, Shaojun
    Ke, Chengjie
    LUNG CANCER, 2024, 196
  • [33] Structure-based drug discovery of MRTX1257, a selective, covalent KRAS G12C inhibitor with oral activity in animal models of cancer.
    Marx, Matthew A.
    Baer, Brian R.
    Ballard, Joshua
    Blake, James F.
    Bouhana, Karyn
    Briere, David M.
    Burgess, Laurence E.
    Burkhard, Michael R.
    Chiang, Harrah
    Chicarelli, Mark J.
    Christensen, James G.
    Fischer, John P.
    Hallin, Jill
    Mejia, Macedonia J.
    Olson, Peter
    Savechenkov, Pavel
    Sudhakar, Niranjan
    Tang, Tony P.
    Vigers, Guy P.
    Fell, Jay B.
    MOLECULAR CANCER RESEARCH, 2020, 18 (05) : 67 - 68
  • [34] Discovery of Novel Noncovalent KRAS G12D Inhibitors through Structure-Based Virtual Screening and Molecular Dynamics Simulations
    Du, Zhenya
    Tu, Gao
    Gong, Yaguo
    Fu, Xiangzheng
    Wu, Qibiao
    Long, Guankui
    MOLECULES, 2024, 29 (06):
  • [35] A novel label-free impedance biosensor for KRAS G12C mutations detection based on PET-RAFT and ROP synergistic signal amplification
    Zhang, Yaping
    Wei, Haiyan
    Guo, Liang
    Gao, Wei
    Cheng, Di
    Liu, Yanju
    BIOELECTROCHEMISTRY, 2025, 161
  • [36] Discovery of novel potent allele-selective KRAS-G12C covalent inhibitors stemming from DNA-encoded library
    McCort, Gary
    Arrebola, Rosalia
    Calvet, Loreley
    Ronan, Baptiste
    Vergne, Fabrice
    Duffieux, Francis
    Rak, Alexey
    Meaux, Isabelle
    Papin, David
    Fassy, Florence
    Delorme, Cecile
    Matthieu, Magali
    Nicolas, Jean-Paul
    Marcireau, Christophe
    Steier, Valerie
    Abecassis, Pierre-Yves
    Czepczor, Valerie
    Thomson, Heather A.
    Hupp, Christopher D.
    Guilinger, J. P.
    Zhang, Ying
    Keefe, Anthony D.
    Cuozzo, John W.
    Liu, Julie
    Debussche, Laurent
    CANCER RESEARCH, 2019, 79 (13)
  • [37] Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects (vol 66, pg 627, 2023)
    Peng, Xiaopeng
    Ren, Yichang
    Pan, Wanyi
    Liu, Jin
    Chen, Jianjun
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (15) : 13507 - 13508
  • [38] 1664: Combination of LUNA18, a novel RAS inhibitor, with KRAS G12C inhibitors augments anti-tumor activity via inhibition of MAPK pathway reactivation
    Michisaka, Saki
    Sase, Hitoshi
    Tachibana, Yukako
    Hasegawa, Masami
    Fujii, Toshihiko
    Kuramoto, Shino
    Shibahara, Norihito
    Ohta, Atsushi
    Tanada, Mikihisa
    Shiraishi, Takuya
    Iikura, Hitoshi
    Kitazawa, Takehisa
    Tanaka, Hiroshi
    CANCER RESEARCH, 2024, 84 (06)
  • [39] Identification of Dietary Bioflavonoids as Potential Inhibitors against KRAS G12D Mutant-Novel Insights from Computer-Aided Drug Discovery
    Ramalingam, Prasanna Srinivasan
    Balakrishnan, Purushothaman
    Rajendran, Senthilnathan
    Jothi, Arunachalam
    Ramalingam, Rajasekaran
    Arumugam, Sivakumar
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2023, 45 (03) : 2136 - 2156
  • [40] Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity (vol 12, 972372, 2022)
    Zhao, Qian
    Xiong, Shan-Shan
    Chen, Can
    Zhu, Hong-Ping
    Xie, Xin
    Peng, Cheng
    He, Gu
    Han, Bo
    FRONTIERS IN ONCOLOGY, 2023, 13
12345