Ru(II)-catalyzed cyclization of 1-aryl-5-aminopyrazoles and α-diazolidinones for one-pot synthesis of benzopyrazole[1,3]diazepines in H2O/EtOH

被引：0

作者：

Liu, Fu-Rao ^{[1
]}

Ren, Jun-Jie ^{[1
]}

Wang, Meng-Yao ^{[1
]}

Liu, Hao-Yu ^{[1
]}

Cao, Jian-Kang ^{[1
]}

Ding, Yu ^{[1
]}

Xue, Zi-Han ^{[1
]}

Zhang, Xin-Shuang ^{[1
]}

Zhu, Yan-Ping ^{[1
,2
]}

Sun, Yuan-Yuan ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharm, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Minist Educ,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Shandong, Peoples R China

[2] Nanjing Forestry Univ, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China

来源：

TETRAHEDRON | 2024年 / 160卷

基金：

中国国家自然科学基金;

关键词：

Benzopyrazole[1,3]diazepines; 1-Aryl-5-aminopyrazoles; alpha-Azolidinone; Ru(II)-Catalyzed protocol; H2O/EtOH; Zn(OAc)(2); VINYL AZIRIDINES; O-ARYLANILINES; ANNULATION; CYCLOADDITION; HETEROCYCLES; ALKYNES; DIAZEPINE; ACCESS;

D O I：

10.1016/j.tet.2024.134047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient Ru(II)-catalyzed protocol has been developed for the synthesis of benzopyrazole [1,3]diazepines in H2O/EtOH with Zn(OAc)2 as an additive. The reaction proceeds without oxidizing agent from 1-aryl-5-aminopyrazoles and alpha-azolidinone to obtain benzopyrazole [1,3]diazepines. This approach has the advantages of a wide range of substrates and high functional group compatibility. The gram-scale experiment demonstrated the potential applications of this reaction.

引用

页数：8

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