Benzothiazole-Directed Enantioselective Borylation of Secondary Benzylic C-H Bonds Using Iridium Catalysis

被引：2
作者：
Xie, Liang-Jun [1 ,2 ]
Chen, Lili [1 ,3 ]
Xu, Senmiao [1 ,3 ]
机构：
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Chinese Acad Sci, Lanzhou Inst Chem Phys, Suzhou Res Inst, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2024年 / 56卷 / 17期
关键词：
asymmetric catalysis; borylation; chiral bidentate boryl ligands; C-H activation; synthetic methods; C(SP(3))-H BONDS; FUNCTIONALIZATION;
D O I：
10.1055/a-2335-8677
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reported here is the iridium-catalyzed regio- and enantio-selective secondary benzylic C-H borylation using benzothiazole as the directing group. Various monosubstituted 2-arylalkylbenzo[d]thiazole were well-tolerated, affording the corresponding products in moderate to good yields with good enantioselectivity. The C-B bond in one borylated product could undergo stereospecific transformations to form aseries of C-C and C-heteroatom bonds.
引用
收藏
页码：2638 / 2647
页数：10
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