BCR signaling in germinal center B cell selection

被引：1
作者：
Inoue, Takeshi [1 ]
Baba, Yoshihiro [2 ]
Kurosaki, Tomohiro [3 ,4 ,5 ]
机构：
[1] Univ Tokyo, Pandem Preparedness Infect & Adv Res Ctr UTOPIA, Dept Mol Syst Immunol, Tokyo, Japan
[2] Kyushu Univ, Med Inst Bioregulat, Div Immunol & Genome Biol, Fukuoka, Japan
[3] Osaka Univ, World Premier Int WPI Immunol Frontier Res Ctr, Lab Lymphocyte Differentiat, Osaka, Japan
[4] Osaka Univ, Ctr Infect Dis Educ & Res, Osaka, Japan
[5] RIKEN Ctr Integrat Med Sci IMS, Lab Lymphocyte Differentiat, Yokohama, Kanagawa, Japan
来源：
TRENDS IN IMMUNOLOGY | 2024年 / 45卷 / 09期
基金：
日本学术振兴会;
关键词：
FOLLICULAR HELPER-CELL; TRANSCRIPTION FACTOR; DARK ZONE; SOLUBLE-ANTIGEN; PI3; KINASE; RECEPTOR; DIFFERENTIATION; ENTRY; STIM1; IMMUNOGLOBULIN;
D O I：
10.1016/j.it.2024.07.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
When mature B cells are activated by antigens, the selection of these activated cells takes place particularly during T cell-dependent immune responses in which an improved antibody repertoire is generated through somatic hypermutation germinal centers (GCs). In this process the importance of antigen presentation by GC B cells, and subsequent T follicular helper (Tfh) cell help in positive selection of GC B cells, has been well appreciated. By contrast, the role of B cell receptor (BCR) signaling per se remains unclear. Strong experimental support for involvement of BCR signaling in GC B cell selection has now been provided. Interestingly, these studies suggest that several checkpoints operating through BCR ensure affinity i nity maturation.
引用
收藏
页码：693 / 704
页数：12
相关论文
共 50 条
  • [41] STAT3 Signaling in B Cells Is Critical for Germinal Center Maintenance and Contributes to the Pathogenesis of Murine Models of Lupus
    Ding, Chuanlin
    Chen, Xingguo
    Dascani, Paul
    Hu, Xiaoling
    Bolli, Roberto
    Zhang, Huang-ge
    Mcleish, Kenneth R.
    Yan, Jun
    JOURNAL OF IMMUNOLOGY, 2016, 196 (11) : 4477 - 4486
  • [42] Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation
    Chen, Zhian
    Cui, Yanfang
    Yao, Yin
    Liu, Bo
    Yunis, Joseph
    Gao, Xin
    Wang, Naiqi
    Canete, Pablo F.
    Tuong, Zewen Kelvin
    Sun, Hongjian
    Wang, Hao
    Yang, Siling
    Wang, Runli
    Leong, Yew Ann
    Davis, David Simon
    Qin, Jiahuan
    Liang, Kaili
    Deng, Jun
    Wang, Conan K.
    Huang, Yen-Hua
    Roco, Jonathan A.
    Nettelfield, Sam
    Zhu, Huaming
    Xu, Huajun
    Yu, Zhijia
    Craik, David
    Liu, Zheng
    Qi, Hai
    Parish, Christopher
    Yu, Di
    SCIENCE IMMUNOLOGY, 2023, 8 (80)
  • [43] Distinct metabolic requirements regulate B cell activation and germinal center responses
    Sharma, Rahul
    Smolkin, Ryan M.
    Chowdhury, Priyanka
    Fernandez, Keith Conrad
    Kim, Youngjun
    Cols, Montserrat
    Alread, William
    Yen, Wei-Feng
    Hu, Wei
    Wang, Zhong-Min
    Violante, Sara
    Chaligne, Ronan
    Li, Ming O.
    Cross, Justin R.
    Chaudhuri, Jayanta
    NATURE IMMUNOLOGY, 2023, 24 (8) : 1358 - 1369
  • [44] CD40 signaling-germinal center b cells go at their own pace
    Liechti, Thomas
    CYTOMETRY PART A, 2019, 95A (04) : 419 - 421
  • [45] T-cell help in the germinal center: homing in on the role of IL-21
    Petersone, Lina
    Walker, Lucy S. K.
    INTERNATIONAL IMMUNOLOGY, 2024, 36 (03) : 89 - 98
  • [46] Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion
    Hillion, Sophie
    Miranda, Anjelica
    Le Dantec, Christelle
    Boudigou, Marina
    Le Pottier, Laetitia
    Cornec, Divi
    Torres, Raul M.
    Pelanda, Roberta
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [47] Positive selection of IgG+ over IgM+ B cells in the germinal center reaction
    Sundling, Christopher
    Lau, Angelica W. Y.
    Bourne, Katherine
    Young, Clara
    Laurianto, Candy
    Hermes, Jana R.
    Menzies, Rosemary J.
    Butt, Danyal
    Krautler, Nike J.
    Zahra, David
    Suan, Dan
    Brink, Robert
    IMMUNITY, 2021, 54 (05) : 988 - +
  • [48] Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone
    Kerfoot, Steven M.
    Yaari, Gur
    Patel, Jaymin R.
    Johnson, Kody L.
    Gonzalez, David G.
    Kleinstein, Steven H.
    Haberman, Ann M.
    IMMUNITY, 2011, 34 (06) : 947 - 960
  • [49] Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches
    Haberman, Ann M.
    Gonzalez, David G.
    Wong, Patrick
    Zhang, Ting-ting
    Kerfoot, Steven M.
    IMMUNOLOGICAL REVIEWS, 2019, 288 (01) : 10 - 27
  • [50] Affinity-based selection and the germinal center response
    Chan, Tyani D.
    Brink, Robert
    IMMUNOLOGICAL REVIEWS, 2012, 247 : 11 - 23
12345