A novel NIR-II fluorescent probe for hydrogen peroxide detection in drug-induced liver injury

被引：0

作者：

Chen, Huiyu ^{[1
]}

Zhou, Hui ^{[1
]}

Zhang, Xinyue ^{[1
]}

Ding, Yancheng ^{[1
]}

Zhang, Xiaolong ^{[1
]}

Xu, Qinqin ^{[1
]}

Wang, Ben ^{[1
]}

Yin, Chao ^{[1
]}

Fan, Quli ^{[1
]}

机构：

[1] Inst Adv Mat IAM, Sch Mat Sci & Engn, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, State Key Lab Organ Elect & Informat Displays,Jian, Nanjing, Jiangsu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 71期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1039/d4cc03512g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of H2O2-activatable small molecules in the second near-infrared (NIR-II) window remains challenging. We present the NIR-II probe Z-1065 for real-time detection of H2O2. Z-1065 demonstrates high sensitivity and selectivity towards H2O2in vitro and effectively monitors H2O2 generation in drug-induced liver injury (DILI) mouse models. A mitochondria-targeted NIR-II probe based on thiopyrylium structure was synthesized for H2O2 detection and drug-induced liver injury (DILI) diagnosis.

引用

页码：9618 / 9621

页数：4

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