Life-Threatening Arrhythmias in Patients With Takotsubo Syndrome Insights Into Pathophysiology and Treatment Innovations

被引：4

作者：

La Vecchia, Giulia ^{[1
,2
]}

Del Buono, Marco Giuseppe ^{[3
]}

Sanna, Tommaso ^{[3
]}

Capecchi, Pier Leopoldo ^{[4
]}

Lazzerini, Pietro Enea ^{[4
]}

Golino, Michele ^{[5
,6
,7
]}

Kron, Jordana ^{[5
]}

Rodriguez-Miguelez, Paula ^{[8
,9
]}

Pelargonio, Gemma ^{[3
]}

Abbate, Antonio ^{[6
,7
]}

机构：

[1] Sacred Heart Catholic Univ, Dept Cardiovasc & Pulm Sci, Rome, Italy

[2] Isola Tiberina Gemelli Isola, Operat Unit Diagnost Intervent Cardiol, Rome, Italy

[3] Fdn Policlin Univ A Gemelli IRCCS, Dept Cardiovasc Med, Rome, Italy

[4] Univ Siena, Univ Hosp Le Scotte, Dept Med Sci Surg & Neurosci, Div Internal Med,Electroimmunol Unit, Siena, Italy

[5] Virginia Commonwealth Univ, Pauley Heart Ctr, Richmond, VA USA

[6] Univ Virginia, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA USA

[7] Univ Virginia, Div Cardiol, Charlottesville, VA USA

[8] Virginia Commonwealth Univ, Dept Kinesiol & Hlth Sci, Richmond, VA USA

[9] Virginia Commonwealth Univ, Div Pulm & Crit Care, Richmond, VA USA

来源：

JACC-CLINICAL ELECTROPHYSIOLOGY | 2024年 / 10卷 / 08期

关键词：

arrhythmias; autonomic modulation; QT prolongation; stress cardiomyopathy; CARDIAC SYMPATHETIC DENERVATION; VENTRICULAR-ARRHYTHMIAS; CLINICAL-FEATURES; NEUROPEPTIDE-Y; CARDIOMYOPATHY; PREDICTORS; MANAGEMENT; OUTCOMES; DISEASE; EVENTS;

D O I：

10.1016/j.jacep.2024.03.034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Takotsubo syndrome (TTS) is a reversible form of acute myocardial injury due to a neurocardiogenic mechanism associated with a relevant risk for life-threatening ventricular arrhythmias, occurring in up to 25% of all patients and including both ventricular arrhythmias (especially) in the context of QT prolongation and atrial tachy- or bradyarrhythmias. The pathogenetic mechanisms of TTS-related arrhythmic complications are not completely understood, and there are no randomized clinical trials addressing the pharmacologic and nonpharmacologic management in this specific setting. In this narrative review, the authors provide an overview of the pathogenesis and the therapeutic management of arrhythmic complications in patients with TTS, along with the future perspectives and the remaining knowledge gaps in this field. (JACC Clin Electrophysiol 2024;10:1943-1952) (c) 2024 by the American College of Cardiology Foundation.

引用

页码：1943 / 1952

页数：10

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