Wall Shear Stress (WSS) Analysis in Atherosclerosis in Partial Ligated Apolipoprotein E Knockout Mouse Model through Computational Fluid Dynamics (CFD)
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作者:
Cho, Minju
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Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
Cho, Minju
[1
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Hwang, Joon Seup
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Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
Hwang, Joon Seup
[1
]
Kim, Kyeong Ryeol
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Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
Kim, Kyeong Ryeol
[1
]
Kim, Jun Ki
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Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
Asan Med Ctr, Asan Inst Life Sci, Biomed Engn Res Ctr, Seoul 05505, South KoreaUniv Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
Kim, Jun Ki
[1
,2
]
机构:
[1] Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
[2] Asan Med Ctr, Asan Inst Life Sci, Biomed Engn Res Ctr, Seoul 05505, South Korea
Atherosclerosis involves an inflammatory response due to plaque formation within the arteries, which can lead to ischemic stroke and heart disease. It is one of the leading causes of death worldwide, with various contributing factors such as hyperlipidemia, hypertension, obesity, diabetes, and smoking. Wall shear stress (WSS) is also known as a contributing factor of the formation of atherosclerotic plaques. Since the causes of atherosclerosis cannot be attributed to a single factor, clearly understanding the mechanisms and causes of its occurrence is crucial for preventing the disease and developing effective treatment strategies. To better understand atherosclerosis and define the correlation between various contributing factors, computational fluid dynamics (CFD) analysis is primarily used. CFD simulates WSS, the frictional force caused by blood flow on the vessel wall with various hemodynamic changes. Using apolipoprotein E knockout (ApoE-KO) mice subjected to partial ligation and a high-fat diet at 1-week, 2-week, and 4-week intervals as an atherosclerosis model, CFD analysis was conducted along with the reconstruction of carotid artery blood flow via magnetic resonance imaging (MRI) and compared to the inflammatory factors and pathological staining. In this experiment, a comparative analysis of the effects of high WSS and low WSS was conducted by comparing the standard deviation of time-averaged wall shear stress (TAWSS) at each point within the vessel wall. As a novel approach, the standard deviation of TAWSS within the vessel was analyzed with the staining results and pathological features. Since the onset of atherosclerosis cannot be explained by a single factor, the aim was to find the correlation between the thickness of atherosclerotic plaques and inflammatory factors through standard deviation analysis. As a result, the gap between low WSS and high WSS widened as the interval between weeks in the atherosclerosis mouse model increased. This finding not only linked the occurrence of atherosclerosis to WSS differences but also provided a connection to the causes of vulnerable plaques.
机构:
Chonbuk Natl Univ, Med Sch, Jeonju 561756, South KoreaChonbuk Natl Univ, Med Sch, Jeonju 561756, South Korea
Choi, Jong-Beum
Park, Young-Ran
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Chonbuk Natl Univ, Coll Engn, Div Chem Engn, Jeonju 561756, South KoreaChonbuk Natl Univ, Med Sch, Jeonju 561756, South Korea
Park, Young-Ran
Kim, Shang-Jin
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Chonbuk Natl Univ, Korea Zoonosis Res Inst, Coll Vet Med, Dept Pharmacol, Jeonju 561756, South KoreaChonbuk Natl Univ, Med Sch, Jeonju 561756, South Korea
Kim, Shang-Jin
Kang, Hyung-Sub
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Chonbuk Natl Univ, Korea Zoonosis Res Inst, Coll Vet Med, Dept Pharmacol, Jeonju 561756, South KoreaChonbuk Natl Univ, Med Sch, Jeonju 561756, South Korea
Kang, Hyung-Sub
Park, Byung-Yong
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Chonbuk Natl Univ, Coll Vet Med, Dept Vet Anat, Jeonju 561756, South KoreaChonbuk Natl Univ, Med Sch, Jeonju 561756, South Korea
Park, Byung-Yong
Kim, In-Shik
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Chonbuk Natl Univ, Coll Vet Med, Dept Vet Anat, Jeonju 561756, South KoreaChonbuk Natl Univ, Med Sch, Jeonju 561756, South Korea
Kim, In-Shik
Yang, Yeong-Seok
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Woosuk Univ, Div Pharmaceut Engn, Samnye Eup 565701, Wanju, South KoreaChonbuk Natl Univ, Med Sch, Jeonju 561756, South Korea
Yang, Yeong-Seok
Kim, Gi-Beum
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Chonbuk Natl Univ, Med Sch, Jeonju 561756, South Korea
Chonbuk Natl Univ, Coll Engn, Div Chem Engn, Jeonju 561756, South Korea
HYOLIM E&I Co Ltd, Seoul 143802, South KoreaChonbuk Natl Univ, Med Sch, Jeonju 561756, South Korea
机构:
Capital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R ChinaCapital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China
Jing Li-na
Gao Pei-yi
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Capital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R ChinaCapital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China
Gao Pei-yi
Lin Yan
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Capital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R ChinaCapital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China
Lin Yan
Sui Bin-bin
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Capital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R ChinaCapital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China
Sui Bin-bin
Qin Hai-qiang
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Capital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R ChinaCapital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China
Qin Hai-qiang
Ma Li
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Capital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R ChinaCapital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China
Ma Li
Xue Jing
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Capital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R ChinaCapital Med Univ, Affiliated Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China
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Asan Med Ctr, Biomed Engn Res Ctr, Seoul, South KoreaAsan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
Lee, Sanghwa
Jue, Miyeon
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Asan Med Ctr, Biomed Engn Res Ctr, Seoul, South KoreaAsan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
Jue, Miyeon
Cho, Minju
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Asan Med Ctr, Biomed Engn Res Ctr, Seoul, South KoreaAsan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
Cho, Minju
Lee, Kwanhee
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Asan Med Ctr, Biomed Engn Res Ctr, Seoul, South KoreaAsan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
Lee, Kwanhee
Paulson, Bjorn
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Asan Med Ctr, Biomed Engn Res Ctr, Seoul, South KoreaAsan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
Paulson, Bjorn
Jo, Hanjoong
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Emory Univ, Wallace H Coulter Dept Biomed Engn, Atlanta, GA USA
Georgia Inst Technol, Atlanta, GA USAAsan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
Jo, Hanjoong
Song, Joon Seon
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Univ Ulsan, Asan Med Ctr, Dept Pathol, Coll Med, Seoul, South KoreaAsan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
Song, Joon Seon
Kang, Soo-Jin
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Univ Ulsan, Asan Med Ctr, Dept Cardiol, Coll Med, Seoul, South Korea
Univ Ulsan, Asan Med Ctr, Dept Cardiol, Coll Med, 88, Olymp ro 43 Gil, Seoul 05505, South KoreaAsan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
Kang, Soo-Jin
Kim, Jun Ki
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Asan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
Univ Ulsan, Coll Med, Dept Biomed Engn, Seoul, South Korea
Univ Ulsan, Dept Biomed Engn, Coll Med, Seoul 05505, South KoreaAsan Med Ctr, Biomed Engn Res Ctr, Seoul, South Korea
机构:
Stanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
LaDisa, John F., Jr.
Olson, Lars E.
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Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Olson, Lars E.
Hettrick, Douglas A.
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机构:
Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Hettrick, Douglas A.
Warltier, David C.
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机构:
Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Med Coll Wisconsin, Dept Med, Div Cardiovasc Dis, Milwaukee, WI 53226 USA
Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA
Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Warltier, David C.
Kersten, Judy R.
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Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA
Kersten, Judy R.
Pagel, Paul S.
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机构:
Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA
Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA
Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USAStanford Univ, Dept Pediat, Div Cardiol, Palo Alto, CA 94304 USA