Wall Shear Stress (WSS) Analysis in Atherosclerosis in Partial Ligated Apolipoprotein E Knockout Mouse Model through Computational Fluid Dynamics (CFD)

被引:0
|
作者
Cho, Minju [1 ]
Hwang, Joon Seup [1 ]
Kim, Kyeong Ryeol [1 ]
Kim, Jun Ki [1 ,2 ]
机构
[1] Univ Ulsan, Coll Med, Dept Convergence Med, Brain Korea Project 21, Seoul 05505, South Korea
[2] Asan Med Ctr, Asan Inst Life Sci, Biomed Engn Res Ctr, Seoul 05505, South Korea
基金
新加坡国家研究基金会;
关键词
atherosclerosis; plaque formation; computational fluid dynamics (CFD); wall shear stress (WSS); ApoE-KO mice; standard deviation; ENDOTHELIAL-CELLS; BLOOD-FLOW; INFLAMMATION; MECHANISMS; ARTERIES; RISK;
D O I
10.3390/ijms25189877
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Atherosclerosis involves an inflammatory response due to plaque formation within the arteries, which can lead to ischemic stroke and heart disease. It is one of the leading causes of death worldwide, with various contributing factors such as hyperlipidemia, hypertension, obesity, diabetes, and smoking. Wall shear stress (WSS) is also known as a contributing factor of the formation of atherosclerotic plaques. Since the causes of atherosclerosis cannot be attributed to a single factor, clearly understanding the mechanisms and causes of its occurrence is crucial for preventing the disease and developing effective treatment strategies. To better understand atherosclerosis and define the correlation between various contributing factors, computational fluid dynamics (CFD) analysis is primarily used. CFD simulates WSS, the frictional force caused by blood flow on the vessel wall with various hemodynamic changes. Using apolipoprotein E knockout (ApoE-KO) mice subjected to partial ligation and a high-fat diet at 1-week, 2-week, and 4-week intervals as an atherosclerosis model, CFD analysis was conducted along with the reconstruction of carotid artery blood flow via magnetic resonance imaging (MRI) and compared to the inflammatory factors and pathological staining. In this experiment, a comparative analysis of the effects of high WSS and low WSS was conducted by comparing the standard deviation of time-averaged wall shear stress (TAWSS) at each point within the vessel wall. As a novel approach, the standard deviation of TAWSS within the vessel was analyzed with the staining results and pathological features. Since the onset of atherosclerosis cannot be explained by a single factor, the aim was to find the correlation between the thickness of atherosclerotic plaques and inflammatory factors through standard deviation analysis. As a result, the gap between low WSS and high WSS widened as the interval between weeks in the atherosclerosis mouse model increased. This finding not only linked the occurrence of atherosclerosis to WSS differences but also provided a connection to the causes of vulnerable plaques.
引用
收藏
页数:14
相关论文
共 13 条
  • [1] Cyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis
    Belton, OA
    Duffy, A
    Toomey, S
    Fitzgerald, DJ
    CIRCULATION, 2003, 108 (24) : 3017 - 3023
  • [2] Pressure distribution and wall shear stress in stenosis and abdominal aortic aneurysm by computational fluid dynamics modeling (CFD)
    Choi, Jong-Beum
    Park, Young-Ran
    Kim, Shang-Jin
    Kang, Hyung-Sub
    Park, Byung-Yong
    Kim, In-Shik
    Yang, Yeong-Seok
    Kim, Gi-Beum
    KOREAN JOURNAL OF CHEMICAL ENGINEERING, 2014, 31 (03) : 402 - 411
  • [3] Pressure distribution and wall shear stress in stenosis and abdominal aortic aneurysm by computational fluid dynamics modeling (CFD)
    Jong-Beum Choi
    Young-Ran Park
    Shang-Jin Kim
    Hyung-Sub Kang
    Byung-Yong Park
    In-Shik Kim
    Yeong-Seok Yang
    Gi-Beum Kim
    Korean Journal of Chemical Engineering, 2014, 31 : 402 - 411
  • [4] Computational Fluid Dynamics (CFD) Model for Analysing the Role of Shear Stress in Angiogenesis in Rheumatoid Arthritis
    Motlana, Malaika K.
    Ngoepe, Malebogo N.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
  • [5] Impact of competitive flow on wall shear stress in coronary surgery: computational fluid dynamics of a LIMA-LAD model
    Nordgaard, Havard
    Swillens, Abigail
    Nordhaug, Dag
    Kirkeby-Garstad, Idar
    Van Loo, Denis
    Vitale, Nicola
    Segers, Patrick
    Haaverstad, Rune
    Lovstakken, Lasse
    CARDIOVASCULAR RESEARCH, 2010, 88 (03) : 512 - 519
  • [6] Distribution of wall shear stress in carotid plaques using magnetic resonance imaging and computational fluid dynamics analysis: a preliminary study
    Jing Li-na
    Gao Pei-yi
    Lin Yan
    Sui Bin-bin
    Qin Hai-qiang
    Ma Li
    Xue Jing
    CHINESE MEDICAL JOURNAL, 2011, 124 (10) : 1465 - 1469
  • [7] Label-free atherosclerosis diagnosis through a blood drop of apolipoprotein E knockout mouse model using surface-enhanced Raman spectroscopy validated by machine learning algorithm
    Lee, Sanghwa
    Jue, Miyeon
    Cho, Minju
    Lee, Kwanhee
    Paulson, Bjorn
    Jo, Hanjoong
    Song, Joon Seon
    Kang, Soo-Jin
    Kim, Jun Ki
    BIOENGINEERING & TRANSLATIONAL MEDICINE, 2023, 8 (04)
  • [8] Investigations Using a Combination of Computational Fluid Dynamics Technique and an Animal Model of Experimentally Induced Cerebral Aneurysms Suggest Important Roles of Wall Shear Stress on the Cerebral Aneurysm Development
    Fukuda, Shunichi
    Shimogonya, Yuji
    Fukuda, Miyuki
    Hasegawa, Koji
    STROKE, 2015, 46
  • [9] The influence of flow distribution strategy for the quantification of pressure- and wall shear stress-derived parameters in the coronary artery: A CTA-based computational fluid dynamics analysis
    Shi, Yibing
    Zheng, Jin
    Zhang, Ying
    Sun, Quanlin
    Shen, Jinhua
    Gao, Yongguang
    Sun, Jingxi
    Yang, Ning
    Zhou, Xuanxuan
    Li, Suqing
    Weir-McCall, Jonathan R.
    Xia, Ping
    Teng, Zhongzhao
    JOURNAL OF BIOMECHANICS, 2023, 161
  • [10] Axial stent strut angle influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics models of stent foreshortening
    LaDisa, John F., Jr.
    Olson, Lars E.
    Hettrick, Douglas A.
    Warltier, David C.
    Kersten, Judy R.
    Pagel, Paul S.
    BIOMEDICAL ENGINEERING ONLINE, 2005, 4 (1)