Virus-specific T cell therapy to treat refractory viral infections in solid organ transplant recipients

被引：3

作者：

Schweitzer, Lorne ^{[1
,3
]}

Muranski, Pawel ^{[2
,3
]}

机构：

[1] Columbia Univ, Irving Med Ctr, Dept Med, Div Infect Dis, New York, NY USA

[2] Columbia Univ, Irving Med Ctr, Dept Med, Div Hematol, New York, NY 10032 USA

[3] Columbia Ctr Translat Immunol, New York, NY USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2024年 / 24卷 / 09期

关键词：

virus-specific T cells; Epstein-Barr Virus; cytomegalovirus; adenovirus; BK virus; JC virus; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; RESISTANT CYTOMEGALOVIRUS DISEASE; ADOPTIVE TRANSFER; BONE-MARROW; LYMPHOCYTES; EBV; IMMUNOTHERAPY; MANAGEMENT; IMMUNITY; PATIENT;

D O I：

10.1016/j.ajt.2024.05.019

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Solid organ transplant recipients require ongoing immunosuppression to prevent acute rejection, which puts them at risk of opportunistic infections. Viral infections are particularly challenging to prevent and treat as many establish latency and thus cannot be eliminated, whereas targets for small molecule antiviral medications are limited. Resistance to antivirals and unacceptable toxicity also complicate treatment. Virus-specific T cell therapies aim to restore host-specific immunity to opportunistic viruses that is lacking due to ongoing immunosuppressive therapy. This minireview will provide a state-of-the-art update of the current virus-specific T cell pipeline and translational research that is likely to lead to further treatment options for viral infections in solid organ transplant recipients.

引用

页码：1558 / 1566

页数：9

共 58 条

[1] How I treat posttransplant lymphoproliferative disorder [J].

Amengual, Jennifer E. ;

Pro, Barbara .

BLOOD, 2023, 142 (17) :1426-1437

[2] CRISPR-Cas9-Edited Tacrolimus-Resistant Antiviral T Cells for Advanced Adoptive Immunotherapy in Transplant Recipients [J].

Amini, Leila ;

Wagner, Dimitrios Laurin ;

Roessler, Uta ;

Zarrinrad, Ghazaleh ;

Wagner, Livia Felicitas ;

Vollmer, Tino ;

Wendering, Desiree Jacqueline ;

Kornak, Uwe ;

Volk, Hans-Dieter ;

Reinke, Petra ;

Schmueck-Henneresse, Michael .

MOLECULAR THERAPY, 2021, 29 (01) :32-46

[3] Viral specific T cell therapy in kidney transplant recipients - A single-center experience [J].

Anand, Manish ;

Nysather, Jake ;

McGraw, Gregory ;

Apewokin, Senu ;

Khoury, Ruby ;

Grimley, Michael S. ;

Bumb, Shalini ;

Govil, Amit .

TRANSPLANT INFECTIOUS DISEASE, 2023, 25 (06)

[4] Maribavir for Refractory Cytomegalovirus Infections With or Without Resistance Post-Transplant: Results From a Phase 3 Randomized Clinical Trial [J].

Avery, Robin K. ;

Alain, Sophie ;

Alexander, Barbara D. ;

Blumberg, Emily A. ;

Chemaly, Roy F. ;

Cordonnier, Catherine ;

Duarte, Rafael F. ;

Florescu, Diana F. ;

Kamar, Nassim ;

Kumar, Deepali ;

Maertens, Johan ;

Marty, Francisco M. ;

Papanicolaou, Genovefa A. ;

Silveira, Fernanda P. ;

Witzke, Oliver ;

Wu, Jingyang ;

Sundberg, Aimee K. ;

Fournier, Martha .

CLINICAL INFECTIOUS DISEASES, 2022, 75 (04) :690-701

[5] Large-scale GMP-compliant CRISPR-Cas9-mediated deletion of the glucocorticoid receptor in multivirus-specific T cells [J].

Basar, Rafet ;

Daher, May ;

Uprety, Nadima ;

Gokdemir, Elif ;

Alsuliman, Abdullah ;

Ensley, Emily ;

Ozcan, Gonca ;

Mendt, Mayela ;

Sanabria, Mayra Hernandez ;

Kerbauy, Lucila Nassif ;

Cortes, Ana Karen Nunez ;

Li, Li ;

Banerjee, Pinaki P. ;

Muniz-Feliciano, Luis ;

Acharya, Sunil ;

Fowlkes, Natalie W. ;

Lu, Junjun ;

Li, Sufang ;

Mielke, Stephan ;

Kaplan, Mecit ;

Nandivada, Vandana ;

Bdaiwi, Mustafa ;

Kontoyiannis, Alexander D. ;

Li, Ye ;

Liu, Enli ;

Ang, Sonny ;

Marin, David ;

Brunetti, Lorenzo ;

Gundry, Michael C. ;

Turk, Rolf ;

Schubert, Mollie S. ;

Rettig, Garrett R. ;

McNeill, Matthew S. ;

Kurgan, Gavin ;

Behlke, Mark A. ;

Champlin, Richard ;

Shpall, Elizabeth J. ;

Rezvani, Katayoun .

BLOOD ADVANCES, 2020, 4 (14) :3357-3367

[6] Adoptive Transfer of JC Virus-Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy [J].

Berzero, Giulia ;

Basso, Sabrina ;

Stoppini, Luca ;

Palermo, Andrea ;

Pichiecchio, Anna ;

Paoletti, Matteo ;

Lucev, Federica ;

Gerevini, Simonetta ;

Rossi, Andrea ;

Vegezzi, Elisa ;

Diamanti, Luca ;

Bini, Paola ;

Gastaldi, Matteo ;

Delbue, Serena ;

Perotti, Cesare ;

Seminari, Elena ;

Faraci, Maura ;

Luppi, Mario ;

Baldanti, Fausto ;

Zecca, Marco ;

Marchioni, Enrico ;

Comoli, Patrizia .

ANNALS OF NEUROLOGY, 2021, 89 (04) :769-779

[7] Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors [J].

Bonifacius, Agnes ;

Lamottke, Britta ;

Tischer-Zimmermann, Sabine ;

Schultze-Florey, Rebecca ;

Goudeva, Lilia ;

Heuft, Hans-Gert ;

Arseniev, Lubomir ;

Beier, Rita ;

Beutel, Gernot ;

Cario, Gunnar ;

Froehlich, Birgit ;

Greil, Johann ;

Hansmann, Leo ;

Hasenkamp, Justin ;

Hoefs, Michaela ;

Hundsdoerfer, Patrick ;

Jost, Edgar ;

Kafa, Kinan ;

Kriege, Oliver ;

Kroeger, Nicolaus ;

Mathas, Stephan ;

Meisel, Roland ;

Nathrath, Michaela ;

Putkonen, Mervi ;

Ravens, Sarina ;

Reinhardt, Hans Christian ;

Sala, Elisa ;

Sauer, Martin G. ;

Schmitt, Clemens ;

Schroers, Roland ;

Steckel, Nina Kristin ;

Trappe, Ralf Ulrich ;

Verbeek, Mareike ;

Wolff, Daniel ;

Blasczyk, Rainer ;

Eiz-Vesper, Britta ;

Maecker-Kolhoff, Britta .

JOURNAL OF CLINICAL INVESTIGATION, 2023, 133 (12)

[8] Adoptive T-Cell Therapy of a Lung Transplanted Patient with Severe CMV Disease and Resistance to Antiviral Therapy [J].

Brestrich, G. ;

Zwinger, S. ;

Fischer, A. ;

Schmueck, M. ;

Roehmhild, A. ;

Hammer, M. H. ;

Kurtz, A. ;

Uharek, L. ;

Knosalla, C. ;

Lehmkuhl, H. ;

Volk, H. -D. ;

Reinke, P. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 (07) :1679-1684

[9] Posoleucel in Kidney Transplant Recipients with BK Viremia [J].

Chandraker, Anil ;

Regmi, Anil ;

Gohh, Reginald ;

Sharma, Akhil ;

Woodle, E. Steve ;

Ansari, Mohammed J. ;

Nair, Vinay ;

Chen, Ling-Xin ;

Alhamad, Tarek ;

Norman, Silas ;

Cibrik, Diane ;

Singh, Manpreet ;

Alper, Arnold ;

Jain, Divya ;

Zaky, Ziad ;

Knechtle, Stuart ;

Sharfuddin, Asif ;

Gupta, Gaurav ;

Lonze, Bonnie E. ;

Young, Jo-Anne H. ;

Adey, Deborah ;

Faravardeh, Arman ;

Dadhania, Darshana M. ;

Rossi, Ana P. ;

Florescu, Diana ;

Cardarelli, Francesca ;

Ma, Julie ;

Gilmore, Sarah ;

Vasileiou, Spyridoula ;

Jindra, Peter ;

Wojciechowski, David .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (05) :618-629

[10] Cytotoxic T-lymphocyte therapy for post-transplant lymphoproliferative disorder after solid organ transplantation in children [J].

Chiou, Fang Kuan ;

Beath, Sue V. ;

Wilkie, Gwen M. ;

Vickers, Mark A. ;

Morland, Bruce ;

Gupte, Girish L. .

PEDIATRIC TRANSPLANTATION, 2018, 22 (02)

← 1 2 3 4 5 6 →