Palladium-catalyzed 1,1-aminoxylation of 3-butenoic acid with 2-alkynylanilines

被引：0
|
作者：
Zhang, Jinhui [1 ]
Mao, Lihua [1 ]
Liu, Chao [1 ]
Tan, Xiangwen [1 ]
Wu, Jiahao [1 ]
Wei, Xuefeng [1 ]
Wu, Wanqing [1 ]
Jiang, Huanfeng [1 ]
机构：
[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 70期
基金：
中国国家自然科学基金;
关键词：
Musculoskeletal system;
D O I：
10.1039/d4cc03099k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, a palladium-catalyzed 1,1-aminoxylation of 3-butenoic acid and 2-alkynylanilines has been developed, achieving the installation of two distinct heteroatom motifs across an olefin skeleton. The strategy features a high step and atom economy and good functional group tolerance, which outlines an efficient approach for simultaneously building up gamma-butylactone and indole skeletons. Notably, an external ligand, 2,9-dimethyl-1,10-phenanthroline, has been used to succeed in this protocol to effectively suppress the production of indole byproducts. A novel palladium-catalyzed 1,1-aminoxylation of 3-butenoic acid with 2-alkynylanilines has been developed.
引用
收藏
页码：9404 / 9407
页数：4
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