Palladium-catalyzed 1,1-aminoxylation of 3-butenoic acid with 2-alkynylanilines

被引：0

作者：

Zhang, Jinhui ^{[1
]}

Mao, Lihua ^{[1
]}

Liu, Chao ^{[1
]}

Tan, Xiangwen ^{[1
]}

Wu, Jiahao ^{[1
]}

Wei, Xuefeng ^{[1
]}

Wu, Wanqing ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 70期

基金：

中国国家自然科学基金;

关键词：

Musculoskeletal system;

D O I：

10.1039/d4cc03099k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, a palladium-catalyzed 1,1-aminoxylation of 3-butenoic acid and 2-alkynylanilines has been developed, achieving the installation of two distinct heteroatom motifs across an olefin skeleton. The strategy features a high step and atom economy and good functional group tolerance, which outlines an efficient approach for simultaneously building up gamma-butylactone and indole skeletons. Notably, an external ligand, 2,9-dimethyl-1,10-phenanthroline, has been used to succeed in this protocol to effectively suppress the production of indole byproducts. A novel palladium-catalyzed 1,1-aminoxylation of 3-butenoic acid with 2-alkynylanilines has been developed.

引用

页码：9404 / 9407

页数：4

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