Acute toxicity of hypofractionated radiotherapy for Japanese breast cancer patients after surgery: a single center prospective observational study (HyPORT-BC)

被引:0
|
作者
Nakamura, Masaki [1 ,2 ]
Fujisawa, Takeshi [1 ]
Oyoshi, Hidekazu [1 ]
Zhou, Yuzheng [1 ]
Fukushi, Keiko [1 ]
Hirata, Hidenari [1 ]
Tomizawa, Kento [1 ]
Motegi, Atsushi [1 ]
Hojo, Hidehiro [1 ]
Wakabayashi, Masashi [3 ]
Kano, Kazuto [4 ]
Ohno, Risa [4 ]
Nakamura, Azusa [1 ]
Yamaguchi, Masayuki [2 ,5 ]
Zenda, Sadamoto [1 ]
机构
[1] Natl Canc Ctr Hosp East, Dept Radiat Oncol, 6-5-1 Kashiwanoha, Kashiwa, Chiba 2778577, Japan
[2] Juntendo Univ, Grad Sch Med, Course Adv Clin Res Canc, Tokyo, Japan
[3] Natl Canc Ctr Hosp East, Clin Res Support Off, Biostat Sect, Chiba, Japan
[4] Natl Canc Ctr Hosp East, Dept Radiol Technol, Chiba, Japan
[5] Natl Canc Ctr Hosp East, Dept Radiol, Chiba, Japan
关键词
Breast cancer; Radiotherapy; Adverse event; Hypofractionated; Automated treatment;
D O I
10.1007/s12282-024-01626-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundThis single center prospective observational study was conducted to evaluate the acute toxicity of hypo-fractionated radiotherapy for Japanese breast cancer patients after surgery.MethodsThis study recruited patients who were scheduled for moderately hypo-fractionated radiotherapy including supraclavicular lymph node area (Cohort M) or ultra-hypo-fractionated radiotherapy for the conserved breast (Cohort U) as postoperative treatment for breast cancer. Radiotherapy plans were generated using automated planning system. Irradiation of 42.5 Gy/16 fractions (Cohort M) or 26 Gy/5 fractions (Cohort U) was delivered, and boost irradiation of 10 Gy/5 fractions was added as needed. The primary endpoint was the proportion of grade >= 2 acute adverse events within 90 days. The toxicities were evaluated using CTCAE ver 5.0.ResultsBetween January 2023 and December 2023, 123 patients (81 in Cohort M and 42 in Cohort U) were enrolled. All the included patients were Japanese and completed their planned radiotherapy and were also able to be evaluated for acute adverse events. Grade 1/2/3-5 acute adverse events were observed in 67/12/0 for Cohort M and 31/4/0 for Cohort U. The proportion of grade >= 2 acute adverse events within 90 days was 15% (95% confidence interval 8-24%) for Cohort M and 10% (95% confidence interval 3-23%) for Cohort U.ConclusionsThe proportion of acute toxicity of hypo-fractionated radiotherapy for Japanese breast cancer patients after surgery was shown to be acceptable in this study.
引用
收藏
页码:1176 / 1181
页数:6
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