Serological Outcome in the First Months of Life of Children Born to Mothers with SARS-CoV-2 Infection during Pregnancy

被引:0
|
作者
Pons-Tomas, Gemma [1 ,2 ]
Martinez-de-Albeniz, Irene [3 ]
Rios-Barnes, Maria [2 ,3 ]
Gamell, Anna [2 ,3 ]
Simo-Nebot, Silvia [2 ,3 ,4 ]
Balsells-Mejia, Sol [5 ]
Hernandez-Garcia, Maria [1 ,2 ]
Mele-Casas, Maria [1 ,2 ]
Sanchez, Emilia [6 ]
Monsonis, Manuel [7 ]
Gene, Amadeu [7 ]
Lopez, Marta [8 ]
Salvia, Dolors [8 ]
Garcia-Garcia, Juan-Jose [1 ,2 ,4 ,9 ]
Fortuny, Claudia [2 ,3 ,4 ,9 ]
Fumado, Victoria [2 ,3 ,9 ]
机构
[1] Univ Barcelona, Hosp St Joan Deu, Pediat Dept, Barcelona 08950, Spain
[2] Inst Recerca St Joan Deu IRSJD, Infect Dis & Microbiome, Barcelona 08950, Spain
[3] Hosp St Joan Deu, Infect & Imported Dis Dept, Barcelona 08950, Spain
[4] Consorcio Invest Biomed Red Epidemiol & Salud Publ, Madrid 28029, Spain
[5] Hosp St Joan Deu, Res Promot & Management Dept, Barcelona 08950, Spain
[6] Univ Ramon Llull, Blanquerna Sch Hlth Sci, Barcelona 08022, Spain
[7] Hosp St Joan Deu, Dept Microbiol, Barcelona 08950, Spain
[8] Hosp Clin Maternitat BCNatal Res, Neonatol Serv, Barcelona 08028, Spain
[9] Univ Barcelona, Fac Med & Hlth Sci, Dept Surg & Med Surg Specialties, Barcelona 08036, Spain
来源
CHILDREN-BASEL | 2024年 / 11卷 / 09期
关键词
SARS-CoV-2; children; pregnancy; antibodies transplacental transmission; serology persistence; transmission; ANTIBODY-RESPONSE;
D O I
10.3390/children11091095
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: The objective of this study is to analyze the transplacental transmission of SARS-CoV-2 antibodies, their persistence in newborns, the factors that may influence this transmission, and the protection these antibodies confer over time. Methods: This prospective cohort was conducted in a tertiary pediatric hospital in the Barcelona Metropolitan Region, Spain. It included neonates born to mothers who had SARS-CoV-2 infection during pregnancy or delivery between August 2020 and January 2022. We followed the recruited children for at least six months, and blood tests were performed to determine the presence of SARS-CoV-2 antibodies. Results: A total of 101 children were recruited. Among the serologies performed on children under three months of age, 44/82 were positive (53.7%). Newborns whose mothers presented more severe disease exhibited higher seropositivity odds (coefficient 9.747; p = 0.002). There were increased preterm deliveries when maternal infection occurred closer to the time of delivery. No severe SARS-CoV-2 infections were detected in children during the follow-up. Conclusions: Slightly more than half of the SARS-CoV-2 serologies performed in the first three months were positive. This appears to confer protection during early childhood. The severity of maternal infection is the most significant factor influencing the transmission of antibodies in children born to unvaccinated mothers.
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页数:13
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