Backtracking childhood leukaemia to birth: A battle of addition

被引：0

作者：

Spector, Logan G. ^{[1
]}

de Smith, Adam J. ^{[2
]}

机构：

[1] Univ Minnesota, Med Sch, Dept Pediat, Div Epidemiol & Clin Res, Minneapolis, MN 55455 USA

[2] Univ Southern Calif, Ctr Genet Epidemiol, USC Norris Comprehens Canc Ctr, Keck Sch Med,Dept Populat & Publ Hlth Sci, Los Angeles, CA USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 205卷 / 05期

关键词：

acute lymphoblastic leukemia; infant B-cell precursor; leukemia-forming NUTM1 rearrangement;

D O I：

10.1111/bjh.19747

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Paediatric leukaemia has a long tail of driver mutations each of which must be 'backtracked' to samples taken at birth to identify the prenatal origin of a subtype. Presently, Bardini et al. describe the first successful backtracking of an NUTM1 rearrangement, which sheds light on the biology of this particular alteration. Continued backtracking of NUTM1 rearrangements, and all leukaemia-typical somatic alterations, is necessary to fully understand the prenatal origin of these diseases.

引用

页码：1670 / 1671

页数：2

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