Backtracking childhood leukaemia to birth: A battle of addition

被引：0
|
作者：
Spector, Logan G. [1 ]
de Smith, Adam J. [2 ]
机构：
[1] Univ Minnesota, Med Sch, Dept Pediat, Div Epidemiol & Clin Res, Minneapolis, MN 55455 USA
[2] Univ Southern Calif, Ctr Genet Epidemiol, USC Norris Comprehens Canc Ctr, Keck Sch Med,Dept Populat & Publ Hlth Sci, Los Angeles, CA USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 205卷 / 05期
关键词：
acute lymphoblastic leukemia; infant B-cell precursor; leukemia-forming NUTM1 rearrangement;
D O I：
10.1111/bjh.19747
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Paediatric leukaemia has a long tail of driver mutations each of which must be 'backtracked' to samples taken at birth to identify the prenatal origin of a subtype. Presently, Bardini et al. describe the first successful backtracking of an NUTM1 rearrangement, which sheds light on the biology of this particular alteration. Continued backtracking of NUTM1 rearrangements, and all leukaemia-typical somatic alterations, is necessary to fully understand the prenatal origin of these diseases.
引用
收藏
页码：1670 / 1671
页数：2
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