Drug-induced or associated vasculitis is a prevalent form of vasculitis that resembles primary idiopathic antineutrophil cytoplasmic autoantibody (ANCA) vasculitis (AAV). Cocaine is a diffuse psychostimulant drug and levamisole is a synthetic compound used to cut cocaine. Their abuse may result in a spectrum of autoimmune manifestations which could be categorized into three overlapping clinical pictures: cocaine-induced midline destructive lesion (CIMDL), levamisole-adulterated cocaine (LAC) vasculopathy/vasculitis, and cocaine-induced vasculitis (CIV). The mechanisms by which cocaine use leads to disorders resembling AAV are not well understood. Cocaine can cause autoimmune manifestations ranging from localized nasal lesions to systemic diseases, with neutrophils playing a key role through NETosis and ANCA development, which exacerbates immune responses and tissue damage. Diagnosing and treating these conditions becomes challenging when cocaine and levamisole abuse is not suspected, due to the differences and overlaps in clinical, diagnostic, therapeutic, and prognostic aspects compared to primary idiopathic vasculitides.
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Univ Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, SpainUniv Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, Spain
Alvarez Diaz, Hortensia
Marino Callejo, Ana Isabel
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Univ Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, SpainUniv Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, Spain
Marino Callejo, Ana Isabel
Garcia Rodriguez, Jose Francisco
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Univ Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, SpainUniv Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, Spain
Garcia Rodriguez, Jose Francisco
Rodriguez Pazos, Laura
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Univ Hosp Fermi Hlth Area Ferrol SERGAS, Dept Dermatol, La Coruna, SpainUniv Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, Spain
Rodriguez Pazos, Laura
Gomez Buela, Inmaculada
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Univ Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, SpainUniv Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, Spain
Gomez Buela, Inmaculada
Bermejo Barrera, Ana Maria
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Univ Santiago Cornpostela, Inst Forens Sci Luis Concheiro, Fac Med, Forens Toxicol Serv, La Coruna, SpainUniv Hosp Fermi, Dept Internal Med, Infect Dis Unit, Hlth Area Ferrol SERGAS, La Coruna, Spain
Bermejo Barrera, Ana Maria
AMERICAN JOURNAL OF CASE REPORTS,
2013,
14
: 557
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561
机构:
Christian Med Coll & Hosp, Dept Pediat, Pediat Rheumatol, Vellore 632004, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Pediat, Pediat Rheumatol, Vellore 632004, Tamil Nadu, India
Kocheril, Anu Punnen
Kumar, Sathish T.
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Christian Med Coll & Hosp, Dept Pediat, Pediat Rheumatol, Vellore 632004, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Pediat, Pediat Rheumatol, Vellore 632004, Tamil Nadu, India
Kumar, Sathish T.
Sathishkumar, Dharshini
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Christian Med Coll & Hosp, Dept Dermatol, Vellore, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Pediat, Pediat Rheumatol, Vellore 632004, Tamil Nadu, India