Prenatal origin of NUTM1 gene rearrangement in infant B-cell precursor acute lymphoblastic leukaemia

被引：2

作者：

Bardini, Michela ^{[1
]}

Fazio, Grazia ^{[1
,2
]}

Abascal, Lilia Corral ^{[1
]}

Meyer, Claus ^{[3
]}

Maglia, Oscar ^{[1
]}

Sala, Simona ^{[1
]}

Palamini, Sonia ^{[1
]}

Rebellato, Stefano ^{[1
]}

Marschalek, Rolf ^{[2
]}

Rizzari, Carmelo ^{[4
]}

Biondi, Andrea ^{[2
,4
]}

Cazzaniga, Giovanni ^{[1
,2
]}

机构：

[1] Fdn IRCCS San Gerardo Tintori, Tettamanti Ctr, Via Pergolesi 33, I-20900 Monza, MB, Italy

[2] Univ Milano Bicocca, Sch Med & Surg, Milan, Italy

[3] Goethe Univ, Inst Pharmaceut Biol, DCAL, Frankfurt, Germany

[4] Fdn IRCCS San Gerardo Tintori, Pediat, Monza, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 205卷 / 05期

关键词：

ALL; genes rearrangement; infant leukaemia; NUTM1; prenatal origin; CHONDROITIN SULFATE PROTEOGLYCAN; HUMAN HOMOLOG; NG2; ANTIGEN; ABNORMALITIES; CLASSIFICATION; LANDSCAPE;

D O I：

10.1111/bjh.19685

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rearrangement of NUTM1 gene (NUTM1r) is one of the most frequent aberrations occurring in infants (younger than 1 year at diagnosis) with B-cell precursor Acute Lymphoblastic Leukaemia (BCP-ALL). In this study we had the unique opportunity to analyze the umbilical cord blood (UCB) sample from one infant patient with NUTM1r BCP-ALL. Herein we reported for the first time that NUTM1r infant ALL arise prenatally, as both the patient-specific CUX1::NUTM1 fusion gene, as well as two IG/TR leukaemic markers were already present and detectable in the patient's UCB at birth. Our results clearly demonstrate the prenatal origin of NUTM1r infant BCP-ALL.

引用

页码：1883 / 1888

页数：6

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