A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions

被引：1

作者：

Ibrahim, Ismail A. ^{[1
]}

Nada, Ahmed Hosney ^{[2
]}

Asar, Nada Khalid ^{[3
]}

Ibrahim, Rand ^{[4
]}

Farouk, Rawan Ahmed ^{[5
]}

Al-Qiami, Almonzer ^{[6
]}

Nada, Sarah A. ^{[7
]}

Oghyanous, Parisa Alizadeh ^{[8
]}

Noorbakhsh, Seyed Ali ^{[9
]}

机构：

[1] Fenerbahce Univ, Fac Hlth Sci, Istanbul, Turkiye

[2] Benha Univ, Fac Med, Banha, Egypt

[3] Mansoura Univ, Fac Med, Mansoura, Egypt

[4] Univ Aleppo, Fac Med, Aleppo, Syria

[5] Al Fayoum Univ, Fac Med, Faiyum, Egypt

[6] Kassala Univ, Fac Med & Hlth Sci, Kassala, Sudan

[7] Menoufia Univ, Fac Med, Shibin Al Kawm, Egypt

[8] Islamic Azad Univ, South Tehran Branch, Tehran, Iran

[9] Sciencebeam Inst, Istanbul, Turkiye

来源：

EXPERIMENTAL GERONTOLOGY | 2024年 / 196卷

关键词：

TDCs; Obsessive-compulsive disorder; Non-pharmacological approach; Transcranial direct current stimulation; Y-BOCS; Neuromodulation; OBSESSIVE-COMPULSIVE DISORDER;

D O I：

10.1016/j.exger.2024.112551

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Obsessive-compulsive disorder (OCD) is a prevalent mental condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions), significantly disrupting daily functioning and social interactions. Transcranial direct current stimulation (tDCS) presents a promising non-invasive treatment modality aimed at alleviating symptoms. However, the evidence regarding its effectiveness remains inconclusive. This study seeks to address this gap by conducting a systematic review and meta-analysis of clinical trials, offering improved guidance for clinical intervention. A comprehensive search strategy was implemented across multiple databases, including PubMed, Cochrane CENTRAL, Embase, Scopus, and Web of Science. This search focused strictly on randomized controlled trials (RCTs) involving 147 patients. These trials evaluated the efficacy of tDCS in OCD patients. Subsequent data extraction, risk of bias assessment, and statistical analysis using Review Manager software revealed the potential efficacy of tDCS in reducing OCD symptoms. The meta-analysis not only fails to demonstrate significant superiority of active tDCS over sham tDCS but also suggests that sham tDCS may be more effective than active tDCS in reducing OCD symptoms. This finding diminishes the promise of tDCS as an effective treatment for OCD. Larger trials are warranted to further elucidate these findings.

引用

页数：7

共 20 条

[1] Deep brain stimulation: foundations and future trends [J].