Advances in the treatment of solid tumors in children and adolescents

Tumor is one of the leading causes of death in children (0 to 14-year-old) and adolescents (15 to 19-year-old) worldwide. Unlike adult tumors, childhood and adolescent tumors are unique in their type, molecular characteristics, and pathogenesis, and their treatment involves many challenges. In recent years, with the development of a large number of clinical studies, the survival rate of children and adolescents with tumors has improved significantly. The extensive research and application of optimized treatment regimens and new targeted drugs have led to new hope for the treatment of childhood and adolescent tumors. This article reviews the clinical and basic research and treatment of childhood and adolescent tumors and provides new ideas for the future development of precise treatment of childhood and adolescent tumors. The tumor is one of the threats to children and adolescents' life and health, causing death and reduced quality of life. But there are few studies on them. Improving the survival rate and survival time of patients is our common goal. We reviewed the literature in recent years, and summarized the new progress achieved in terms of chemotherapy regimens, molecular targeted drugs, and immunotherapy, to provide new ideas for the treatment of tumors in children and adolescents. image