Prevalence of Sexual Dysfunction in Inflammatory Bowel Disease: Systematic Review and Meta-analysis

被引:2
作者
Nardone, Olga Maria [1 ]
Calabrese, Giulio [2 ]
Bertin, Luisa [3 ]
Ford, Alexander C. [4 ,5 ,6 ]
Castiglione, Fabiana
Zingone, Fabiana
Savarino, Edoardo
Barberio, Brigida
机构
[1] Univ Naples Federico II, Dept Publ Hlth, Gastroenterol Unit, Naples, Italy
[2] Univ Naples Federico II, Dept Clin Med & Surg, Gastroenterol Unit, Naples, Italy
[3] Univ Padua, Azienda Osped Univ Padova, Dept Surg Oncol & Gastroenterol, Gastroenterol Unit, Padua, Italy
[4] St James Univ Hosp, Leeds Gastroenterol Inst, Leeds, England
[5] Univ Leeds, Leeds Inst Med Res St Jamess, Leeds, England
[6] Univ Naples Federico II, Dept Publ Hlth Gastroenterol, Via Pansini 5, I-80131 Naples, Italy
关键词
Inflammatory bowel disease; sexual dysfunction; sexuality; WOMEN; INDEX; MEN; PERCEPTIONS; DEPRESSION; HEALTH; SCALE;
D O I
10.1093/ecco-jcc/jjae133
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and Aims Patients with inflammatory bowel disease (IBD) may experience symptoms of sexual dysfunction (SD). However, the magnitude of this problem remains uncertain. Therefore, we performed a systematic review and meta-analysis to assess the prevalence of SD in adult patients with IBD.Methods MEDLINE, EMBASE, and EMBASE Classic (from inception to April 9, 2024) were searched to identify observational studies reporting the prevalence of SD in adult patients with IBD based on validated screening instruments. Data were extracted, and pooled prevalence (PP), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated.Results Of 1017 citations evaluated, 18 articles fulfilled the eligibility criteria, containing 2694 patients with IBD recruited from 13 different countries. The PP of SD in IBD patients was 50.6% (95% CI, 40.8%-60.5%; I2 = 96.3%) with an OR = 2.94 (95% CI, 1.99%-4.35%, I2 = 73.4) compared to healthy controls. When we considered ulcerative colitis (UC) or Crohn's disease (CD) separately, the PP of SD was 64.8% (95% CI, 45.1%-82.1%; I2 = 88.8%) in patients with UC and 58.3% (95% CI, 36.0%-79.0%; I2 = 95.3%) in patients with CD. In the subgroup analysis based on sex, the PP of SD was higher in females with IBD than in males (62.7% vs 34.0%; OR = 3.99, 95% CI, 2.80%-5.68%; I2 = 61.7%). Furthermore, the PP of SD was higher in patients with active disease than in patients with inactive disease (75.1% vs 34.2%; OR = 9.65, 95% CI, 1.02%-91.33%, I2 = 95.5%).Conclusions We demonstrated high prevalence of SD in IBD patients, especially in women. Encouraging gastroenterologists to screen for, and treat, these disorders with a holistic approach might improve quality of life of patients with IBD. Graphical Abstract
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