Transporter Engineering in Microbial Cell Factory Boosts Biomanufacturing Capacity

被引：18
作者：
Lv, Xiaodong [1 ]
Xue, Haijie [1 ]
Qin, Lei [2 ,3 ]
Li, Chun [1 ,2 ,3 ]
机构：
[1] Beijing Inst Technol, Sch Chem & Chem Engn, Key Lab Med Mol Sci & Pharmaceut Engn, Minist Ind & Informat Technol,Inst Biochem Engn, Beijing, Peoples R China
[2] Tsinghua Univ, Dept Chem Engn, Key Lab Ind Biocatalysis, Minist Educ, Beijing, Peoples R China
[3] Tsinghua Univ, Ctr Synthet & Syst Biol, Dept Chem Engn, Beijing, Peoples R China
来源：
BIODESIGN RESEARCH | 2022年 / 2022卷
基金：
中国国家自然科学基金;
关键词：
YEAST SUBCELLULAR COMPARTMENTS; SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI; ACID PRODUCTION; FATTY ALCOHOLS; BIOSYNTHESIS; METABOLISM; PATHWAYS; TOLERANCE; SECRETION;
D O I：
10.34133/2022/9871087
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Microbial cell factories (MCFs) are typical and widely used platforms in biomanufacturing for designing and constructing synthesis pathways of target compounds in microorganisms. In MCFs, transporter engineering is especially significant fi cant for improving the biomanufacturing efficiency ffi ciency and capacity through enhancing substrate absorption, promoting intracellular mass transfer of intermediate metabolites, and improving transmembrane export of target products. This review discusses the current methods and strategies of mining and characterizing suitable transporters and presents the cases of transporter engineering in the production of various chemicals in MCFs.
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页数：8
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