CD45 threads the needle of cytokine cancer immunotherapy

被引：0
|
作者：
Wellhausen, Nils [1 ,2 ,3 ]
Gill, Saar [1 ,2 ,3 ,4 ]
机构：
[1] Univ Penn, Ctr Cellular Immunotherapies, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Translat Ctr Excellence Hematopoiet Stem Cell Engn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Med, Div Hematol Oncol, Philadelphia, PA 19104 USA
[4] Univ Penn, Ctr Cellular Therapy & Transplantat, Abramson Canc Ctr, Philadelphia, PA 19104 USA
来源：
NATURE IMMUNOLOGY | 2024年 / 25卷 / 10期
关键词：
D O I：
10.1038/s41590-024-01956-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunocytokines are cytokine-based fusion proteins with therapeutic potential. New CD45-targeted immunocytokines can reprogram systemic anti-tumor immunity by prolonged retention on T cells and dendritic cells while minimizing systemic toxicities through intratumoral delivery.
引用
收藏
页码：1775 / 1777
页数：3
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