A novel role of ADAMTS16 in renal fibrosis through activating TGF-(3/ Smad signaling

被引：2

作者：

Zhao, Juan ^{[1
,2
,3
]}

Tian, Tongtong ^{[1
,2
]}

Huang, Jing ^{[4
]}

Zha, Hongchu ^{[5
]}

Shi, Lang ^{[4
,6
]}

Yao, Yufeng ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Mol Biophys, 1037 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Ctr Human Genome Res, 1037 Luoyu Rd, Wuhan 430074, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Immunol, Wuhan 430030, Peoples R China

[4] Wuhan Univ, Dept Nephrol, Renmin Hosp, Wuhan 430060, Peoples R China

[5] Three Gorges Univ, Ctr Peoples Hosp Yichang, Dept Nephrol, Clin Med Coll 1, Yichang 443000, Hubei, Peoples R China

[6] Lanzhou Univ, Hosp 1, Dept Nephrol, Lanzhou 730000, Peoples R China

来源：

CELLULAR SIGNALLING | 2024年 / 122卷

基金：

中国国家自然科学基金;

关键词：

Renal fibrosis; Chronic kidney diseases; ADAMTS16; TGF-(3; RRFR; Drug target; LIVER FIBROSIS;

D O I：

10.1016/j.cellsig.2024.111347

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chronic Kidney Disease (CKD) has emerged as a global public health concern, with its primary pathological basis being Renal Fibrosis (RF), crucial to halt its progression to End-Stage Renal Disease (ESRD). However, effective treatment options are currently lacking. Therefore, exploring the mechanisms of RF, identifying drug targets and diagnostic biomarkers are important. In this study, we identified ADAMTS16 as a newly expressed regulatory factor highly expressed in renal fibrosis tissue. ADAMTS16 interacts with latency-associated peptide (LAP)transforming growth factor (TGF)-(3, leading to the activation of TGF-(3. Loss of ADAMTS16 expression effectively reduces TGF-(3-dependent transcription activity. Furthermore, the use of RRFR tetrapeptide derived from ADAMTS16 can activate the TGF-(3/Smad signaling axis, promoting RF. In summary, ADAMTS16 is induced in the progression of CKD, interacting with LAP-TGF-(3 and potentially activating SMAD2/3. Therefore, targeting ADAMTS16 may serve as a crucial new strategy to alleviate RF and treat CKD patients.

引用

页数：12

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