Targeting STAT3 Enzyme for Cancer Treatment

被引：0

作者：

Arun, Sowmiya ^{[1
]}

Patel, Praveen Kumar ^{[1
]}

Lakshmanan, Kaviarasan ^{[2
]}

Rajangopal, Kalirajan ^{[1
]}

Swaminathan, Gomathi ^{[1
]}

Byran, Gowramma ^{[1
]}

机构：

[1] JSS Acad Higher Educ & Res, Dept Pharmaceut Chem, JSS Coll Pharm, Nilgiris 643001, Tamil Nadu, India

[2] Satyabhama Inst Sci & Technol, Sch Pharm, Dept Pharmaceut Chem, Chennai, Tamil Nadu, India

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2024年 / 24卷 / 13期

关键词：

STAT3; inhibitors; SH-2; domain; proliferation; phosphorylation; hematological malignancies; tyrosine residue; NF-KAPPA-B; SIGNAL TRANSDUCER; TRANSCRIPTION; 3; KEY REGULATOR; EXPRESSION; ACTIVATOR; COMMUNICATION; SUPPRESSOR; APOPTOSIS; REVEALS;

D O I：

10.2174/0113895575254012231024062619

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A category of cytoplasmic transcription factors called STATs mediates intracellular signaling, which is frequently generated at receptors on cell surfaces and subsequently sent to the nucleus. STAT3 is a member of a responsible for a variety of human tumor forms, including lymphomas, hematological malignancies, leukemias, multiple myeloma and several solid tumor types. Numerous investigations have demonstrated constitutive STAT3 activation lead to cancer development such as breast, head and neck, lung, colorectal, ovarian, gastric, hepatocellular, and prostate cancers. It's possible to get a hold of the book here. Tumor cells undergo apoptosis when STAT3 activation is suppressed. This review highlights the STAT3 activation and inhibition which can be used for further studies.

引用

页码：1252 / 1261

页数：10

共 67 条

[1]

Abroun S, 2015, CELL J, V17, P395

[2] STAT3β is a tumor suppressor in acute myeloid leukemia [J].