Application of magnetic nanoparticles in adoptive cell therapy of cancer; training, guiding and imaging cells

被引：0
|
作者：
Mohammadi, Vahid [1 ]
Esmaeilzadeh, Kimia [2 ]
Esmaeilzadeh, Abdolreza [3 ,4 ]
机构：
[1] Zanjan Univ Med Sci, Student Res Comm, Sch Med, Zanjan, Iran
[2] Zanjan Univ Med Sci, Sch Med, Dept Med Nanotechnol, Zanjan, Iran
[3] Zanjan Univ Med Sci, Sch Med, Dept Immunol, Zanjan, Iran
[4] Zanjan Univ Med Sci, Canc Gene Therapy Res Ctr CGRC, Zanjan, Iran
来源：
NANOMEDICINE | 2024年 / 19卷 / 27期
关键词：
adoptive cell therapy (ACT); cancer immunotherapy; magnetic nanoparticle (MNP); nanomedicine; superparamagnetic Iron-oxide nanoparticles (SPIONs); IRON-OXIDE NANOPARTICLES; ANTIGEN-PRESENTING CELLS; NATURAL-KILLER-CELLS; SUPERPARAMAGNETIC NANOPARTICLES; PROTEIN CORONA; T-LYMPHOCYTES; TUMOR; MRI; DELIVERY; SIZE;
D O I：
10.1080/17435889.2024.2395239
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Adoptive cell therapy (ACT) is on the horizon as a thrilling therapeutic plan for cancer. However, widespread application of ACT is often restricted by several challenges, including complexity of priming tumor-specific T cells and poor trafficking in solid tumors. The convergence of nanotechnology and cancer immunotherapy is coming of age and could address the limitations of ACT. Recent studies have provided evidence on the application of magnetic nanoparticles (MNPs) to generate smart immune cells and to bypass problems associated with conventional ACT. Herein, we review current progress in the application of MNPs to improve preparing, guiding and tracking immune cells in cancer ACT. Besides, we comment on the challenges ahead and strategies to optimize MNPs for clinical settings.
引用
收藏
页码：2315 / 2329
页数：15
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