Antisperm Antibody Levels After Vasectomy Reversal Are Not Associated With Pregnancy Rates or Method of Conception

被引:2
作者
Nam, Catherine S. [1 ,2 ,3 ]
Tooke, Benjamin P. [1 ,2 ,3 ]
Strasser, Oakley [1 ,2 ,3 ]
Hameed, Mujtaba A. [1 ,2 ,3 ]
Chinnusamy, Sadhana [1 ,2 ,3 ]
Van Til, Monica [1 ,2 ,3 ]
Daignault-Newton, Stephanie [1 ,2 ,3 ]
Dupree, James M. [1 ,2 ,3 ]
机构
[1] Michigan Med Univ Michigan, Dept Urol, Ann Arbor, MI USA
[2] Univ Calif Los Angeles, Dept Urol, Los Angeles, CA USA
[3] Weill Cornell Med, Dept Urol, New York, NY USA
关键词
One hundred sixty-four (80%) patients underwent bilateral vasovasostomy; Eighty-five pa; fecting sperm motility; cervical mucus interaction; ag; MICROSURGICAL VASOVASOSTOMY; SPERM ANTIBODIES; SEMEN PARAMETERS; AUTOANTIBODIES; FERTILITY;
D O I
10.1016/j.urology.2024.02.028
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE To examine the relationship between antisperm antibody (ASA), pregnancy rates, and method of conception following vasectomy reversal, given that before and after vasectomy reversal, patients wonder if ASAs will prevent them from achieving pregnancy and American Urological Association vasectomy guidelines call for additional research to answer this question. METHODS We performed retrospective chart review and phone interview of patients who underwent vasectomy reversal at our institution from 1/1/2000 to 12/31/2018. We excluded patients who underwent vasectomy reversal for pain, or without postoperative semen analysis with ASA. We categorized patients as having low (< 50%) or high (>= 50%) ASA levels using the first postoperative semen analysis. Our primary outcome was pregnancy rate, including method of conception. Differences in pregnancy rates were tested using Fisher exact test. RESULTS Two hundred and four patients were chart reviewed. Median age at time of surgery was 40 years and median obstruction interval was 7.3 years. Median partner age was 32 years. One hundred sixty-four (80%) patients underwent bilateral vasovasostomy. Eighty-five patients (42%) had low (< 50%) ASA levels and 119 (58%) had high (>= 50%) ASA levels. Sixty-seven patients completed phone interviews. Of 27 men with low ASA levels, 19 (70%) achieved a pregnancy with 16 (59%) spontaneous pregnancy. Of 40 men with high ASA levels, 30 (75%) achieved a pregnancy with 16 (40%) spontaneous pregnancy. The Fisher exact test P -value was .2. CONCLUSION ASA levels are not associated with pregnancy rate or method of conception after vasectomy reversal. These findings can improve patient counseling before and after vasectomy reversal. UROLOGY 186: 154-161, 2024. (c) 2024 Elsevier Inc. All rights reserved.
引用
收藏
页码:154 / 161
页数:8
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