The Effect of Bariatric Surgery on PAI-1 Levels: A Systematic Review and Meta-analysis

被引：0
|
作者：
Jamialahamdi, Tannaz [1 ,2 ]
Mirhadi, Elaheh [3 ]
Almahmeed, Wael [4 ]
Sukhorukov, Vasily N. [5 ]
Eid, Ali H. [6 ]
Salehabadi, Sepideh [2 ]
Sahebkar, Amirhossein [7 ,8 ,9 ]
机构：
[1] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Iran
[3] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran
[4] Cleveland Clin Abu Dhabi, Heart & Vasc Inst, Abu Dhabi, U Arab Emirates
[5] Inst Gen Pathol & Pathophysiol, 8 Baltiiskaya St, Moscow 125315, Russia
[6] Qatar Univ, Coll Med, Dept Basic Med Sci, QU Hlth, Doha, Qatar
[7] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Chennai, India
[8] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
[9] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
来源：
OBESITY SURGERY | 2024年 / 34卷 / 10期
基金：
俄罗斯科学基金会;
关键词：
Metabolic surgery; PAI-1; Inflammation; Fibrinolysis; Obesity; PLASMINOGEN-ACTIVATOR INHIBITOR-1; MORBIDLY OBESE-PATIENTS; GASTRIC BYPASS-SURGERY; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; REDUCTION; MARKERS; ATHEROSCLEROSIS; PANCREAS; PARAMETERS;
D O I：
10.1007/s11695-024-07473-1
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The purpose of this meta-analysis was to determine the effect of bariatric surgery on circulating PAI-1. The meta-analysis was provided by comprehensive meta-analysis (CMA) V4 software. Meta-analysis of 33 studies showed a significant decrease in circulating PAI-1 after bariatric surgery (p < 0.001). A significant reduction was observed for two types of surgery) (p < 0.001 for LSG and p < 0.001 for RYGB). Furthermore, there was a significant change in circulating PAI-1 based on the follow-up duration (p < 0.001 for follow-up < 12 months and p < 0.001 for follow-up >= 12). We showed that bariatric surgery changed PAI-1 level significantly and changes in BMI after surgery were not related to PAI-1 alteration. Furthermore, this result was consistent based on follow-up duration and type of surgery.
引用
收藏
页码：3876 / 3887
页数：12
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