Substrate-directed C(sp3)-H borylation via transition metal catalysis: expanding the toolbox for C-H functionalization

被引:1
|
作者
Thalakottukara, Dolly David [1 ]
Sekar, Manikandan [1 ]
Mandal, Astam [2 ]
Gandhi, Thirumanavelan [1 ]
Maiti, Debabrata [2 ]
机构
[1] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India
[2] Indian Inst Technol, Dept Chem, Mumbai 400076, India
关键词
BONDS; CONSTRUCTION; ACTIVATION; ADJACENT; LIGAND;
D O I
10.1039/d4cy00754a
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Organoborons play a crucial role in organic synthesis, easing the construction of C-C and C-X bonds, which in turn sensitize C-H borylation reactions. In the context of inert C(sp(3))-H borylation, significant efforts have been dedicated to achieve site- and chemoselectivity by involving directing groups via transition metal catalysis. This review highlights various types of directing groups that can enable intricate and distal C(sp(3))-H borylation; heteroatoms such as P, N, B, Si, Br, O, and Cl, which are attached to the substrate, act as the directing group. In addition to homogeneous catalysis, the occurrence of heterogeneous catalysis was realized, and the considerable contribution to chiral C(sp(3))-H borylation is discussed. Finally, this review summarizes the mechanistic aspects and late-stage modifications of complex molecules.
引用
收藏
页码:5488 / 5504
页数:17
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