Copper-Catalyzed, Intramolecular Amination of Unactivated C(sp3)-H Bonds through Radical Relay

被引：0
|
作者：
Zuo, Liyan [1 ]
Yu, Fan [1 ]
Zhao, Shuai [2 ]
Wang, Wengui [3 ]
Wang, Shoufeng [3 ]
机构：
[1] Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Peoples R China
[2] Qingdao Zhongda Agritech Co Ltd, Qingdao 266100, Shandong, Peoples R China
[3] Univ Jinan, Sch Chem & Chem Engn, Shandong Prov Key Lab Fluorine Chem & Chem Mat, Jinan 250022, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 18期
基金：
中国国家自然科学基金;
关键词：
MEDIATED DELTA-AMINATION; FUNCTIONALIZATION; HETEROCYCLES;
D O I：
10.1021/acs.joc.4c01163
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Although copper-catalyzed amination of activated C(sp(3))-H bonds through radical relay has been developed, amination of unactivated C(sp(3))-H bonds is rare. Herein, copper-catalyzed intramolecular amination of remote unactivated C(sp(3))-H bonds is reported. The reaction is conducted in a mild and effective manner with moderate to good yields, demonstrating broad tolerance toward various functional groups and exhibiting complete regio- and chemoselectivities. This innovation supplies novel synthetic pathways for the construction of saturated nitrogenated heterocycles.
引用
收藏
页码：13077 / 13084
页数：8
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