Copper-Catalyzed, Intramolecular Amination of Unactivated C(sp3)-H Bonds through Radical Relay

被引：0

作者：

Zuo, Liyan ^{[1
]}

Yu, Fan ^{[1
]}

Zhao, Shuai ^{[2
]}

Wang, Wengui ^{[3
]}

Wang, Shoufeng ^{[3
]}

机构：

[1] Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Peoples R China

[2] Qingdao Zhongda Agritech Co Ltd, Qingdao 266100, Shandong, Peoples R China

[3] Univ Jinan, Sch Chem & Chem Engn, Shandong Prov Key Lab Fluorine Chem & Chem Mat, Jinan 250022, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 18期

基金：

中国国家自然科学基金;

关键词：

MEDIATED DELTA-AMINATION; FUNCTIONALIZATION; HETEROCYCLES;

D O I：

10.1021/acs.joc.4c01163

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Although copper-catalyzed amination of activated C(sp(3))-H bonds through radical relay has been developed, amination of unactivated C(sp(3))-H bonds is rare. Herein, copper-catalyzed intramolecular amination of remote unactivated C(sp(3))-H bonds is reported. The reaction is conducted in a mild and effective manner with moderate to good yields, demonstrating broad tolerance toward various functional groups and exhibiting complete regio- and chemoselectivities. This innovation supplies novel synthetic pathways for the construction of saturated nitrogenated heterocycles.

引用

页码：13077 / 13084

页数：8

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