Single-cell sequencing analysis revealed that WDR72 was a novel cancer stem cells related gene in gastric cancer

被引：2
作者：
Zheng, Lei [1 ]
Lu, Jia [2 ]
Kong, Dalu [1 ]
Zhan, Yang [1 ]
机构：
[1] Tianjin Med Univ Canc Inst & Hosp, Dept Colorectal Oncol, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc,Key Lab Canc Prevent &, Huanhuxi Rd, Tianjin 300060, Peoples R China
[2] Tianjin Med Univ Canc Inst & Hosp, Dept Infect Management, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc,Key Lab Canc Prevent &, Tianjin 300060, Peoples R China
来源：
HELIYON | 2024年 / 10卷 / 15期
关键词：
Cancer stem cells; Gastric cancer; Single-cell sequencing; WDR72; Prognosis; EXPRESSION;
D O I：
10.1016/j.heliyon.2024.e35549
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: Cancer stem cells (CSCs) are pivotal in tumor resistance to chemotherapy and gastric cancer's rapid proliferation and metastasis. We aimed to explore the CSCs-related genes in gastric cancer epithelial cells. Methods: The mRNA expression profile and single-cell sequencing data of gastric cancer were downloaded from the public database. Results: We identified WDR72 as a CSCs-related gene in gastric cancer epithelial cells. WDR72 was highly expressed in gastric cancer tissues, and high expression of WDR72 was associated with inferior prognosis of patients. WDR72 expression had a significant negative correlation with the infiltration of CD8 + T cells and activated memory CD4 + T cells. PD-L1 expression was significantly reduced in gastric cancer patients with high WDR72 expression. WDR72 was correlated with IC50 of multiple small-molecule drugs. Conclusion: We identified a novel CSCs-related gene in gastric cancer epithelial cells, WDR72, which was highly expressed in patients with high stemness scores.
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页数：15
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