Reduction of 2-phenyl-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione with NaBH4: Investigation of exo-selectivity and reaction mechanism via theoretical computations

被引：0

作者：

Gundogdu, Ozlem ^{[1
,4
]}

Atalay, Abdurrahman ^{[2
,3
]}

Turhan, Pinar ^{[4
]}

Anil, Baris ^{[4
]}

Sahin, Ertan ^{[4
]}

Bozkaya, Ugur ^{[2
]}

Kishali, Nurhan H. ^{[4
]}

Kara, Yunus ^{[4
]}

机构：

[1] Ahi Evran Univ, Kaman Vocat Sch, Dept Food Technol, Kirsehir, Turkiye

[2] Hacettepe Univ, Fac Sci, Dept Chem, Ankara, Turkiye

[3] Avrasya Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-61080 Trabzon, Turkiye

[4] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkiye

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2025年 / 1319卷

关键词：

3-hydroxylactam; Acylaminocarbinol; Metal hydride reduction; Bicyclic imide; Theoretical computations; CONVENIENT SYNTHESIS; PHTHALIMIDES; DERIVATIVES; CONVERSION; CANTHARIMIDE; ANALOGS;

D O I：

10.1016/j.molstruc.2024.139520

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The reaction of the bicyclic imide with NaBH4 afforded acylaminocarbinol and carboxamide derivatives. The exact configuration of acylaminocarbinol 7 was determined by X-ray crystal analysis. Theoretical studies were carried out to explain the mechanism of the exo-selectivity observed in the first step of the reduction reaction and the formation of the secondary product in the second step. According to the obtained findings, i) in the first step of the reaction, the exo-path is kinetically more favorable, and ii) an alternative mechanism has been proposed instead of the mechanism proposed in the literature. The canonical forms of the amide group in the lactam ring were found to make an important contribution to the mechanism. iii) The amount of products formed in the reduction reaction depends on the reaction conditions.

引用

页数：7

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