Cellular Components of the Blood-Brain Barrier and Their Involvement in Aging-Associated Cognitive Impairment

被引：2

作者：

Shen, Kaiyuan ^{[1
]}

Shi, Yi ^{[2
,3
]}

Wang, Xin ^{[1
]}

Leung, Susan W. S. ^{[4
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai, Peoples R China

[2] Fudan Univ, Zhongshan Hosp, Inst Clin Sci, Shanghai, Peoples R China

[3] Fudan Univ, Zhongshan Hosp, Key Lab Organ Transplantat, Shanghai, Peoples R China

[4] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Hong Kong, Peoples R China

来源：

AGING AND DISEASE | 2025年 / 16卷 / 03期

关键词：

components; blood-brain barrier; aging; cognitive impairment; ENDOTHELIAL PROGENITOR CELLS; AMYLOID PRECURSOR PROTEIN; CEREBRAL-ARTERY OCCLUSION; PDGF-ALPHA-RECEPTOR; GROWTH-FACTOR-BETA; NITRIC-OXIDE; TGF-BETA; PERIVASCULAR MACROPHAGES; MATRIX METALLOPROTEINASE-2; GLUCOSE-TRANSPORT;

D O I：

10.14336/AD.202.0424

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Human life expectancy has been significantly extended, which poses major challenges to our healthcare and social systems. Aging-associated cognitive impairment is attributed to endothelial dysfunction in the cardiovascular system and neurological dysfunction in the central nervous system. The central nervous system is considered an immune-privileged tissue due to the exquisite protection provided by the blood-brain barrier. The present review provides an overview of the structure and function of blood-brain barrier, extending the cell components of blood-brain barrier from endothelial cells and pericytes to astrocytes, perivascular macrophages and oligodendrocyte progenitor cells. In particular, the pathological changes in the blood-brain barrier in aging, with special focus on the underlying mechanisms and molecular changes, are presented. Furthermore, the potential preventive/therapeutic strategies against aging-associated blood-brain barrier disruption are discussed.

引用

页码：1513 / 1534

页数：22

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