Cellular Components of the Blood-Brain Barrier and Their Involvement in Aging-Associated Cognitive Impairment

被引：2
作者：
Shen, Kaiyuan [1 ]
Shi, Yi [2 ,3 ]
Wang, Xin [1 ]
Leung, Susan W. S. [4 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Inst Clin Sci, Shanghai, Peoples R China
[3] Fudan Univ, Zhongshan Hosp, Key Lab Organ Transplantat, Shanghai, Peoples R China
[4] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Hong Kong, Peoples R China
来源：
AGING AND DISEASE | 2025年 / 16卷 / 03期
关键词：
components; blood-brain barrier; aging; cognitive impairment; ENDOTHELIAL PROGENITOR CELLS; AMYLOID PRECURSOR PROTEIN; CEREBRAL-ARTERY OCCLUSION; PDGF-ALPHA-RECEPTOR; GROWTH-FACTOR-BETA; NITRIC-OXIDE; TGF-BETA; PERIVASCULAR MACROPHAGES; MATRIX METALLOPROTEINASE-2; GLUCOSE-TRANSPORT;
D O I：
10.14336/AD.202.0424
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Human life expectancy has been significantly extended, which poses major challenges to our healthcare and social systems. Aging-associated cognitive impairment is attributed to endothelial dysfunction in the cardiovascular system and neurological dysfunction in the central nervous system. The central nervous system is considered an immune-privileged tissue due to the exquisite protection provided by the blood-brain barrier. The present review provides an overview of the structure and function of blood-brain barrier, extending the cell components of blood-brain barrier from endothelial cells and pericytes to astrocytes, perivascular macrophages and oligodendrocyte progenitor cells. In particular, the pathological changes in the blood-brain barrier in aging, with special focus on the underlying mechanisms and molecular changes, are presented. Furthermore, the potential preventive/therapeutic strategies against aging-associated blood-brain barrier disruption are discussed.
引用
收藏
页码：1513 / 1534
页数：22
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