Prevalence of hepatitis and HIV infection among 18-months old children in Guinea-Bissau before vaccination

被引：0
|
作者：
Dutschke, Alexander [1 ,2 ,3 ]
Agergaard, Jane [1 ]
Medina, Candida [2 ]
Honge, Bo Langhoff [1 ,2 ]
机构：
[1] Aarhus Univ Hosp, Dept Infect Dis, Palle Juul Jensens Blvd 99, DK-8200 Aarhus, Denmark
[2] Indepth Network, Bandim Hlth Project, Bissau, Guinea Bissau
[3] Aarhus Univ, Sch Publ Hlth, Ctr Global Hlth, GloHAU, Aarhus, Denmark
来源：
TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2024年 / 29卷 / 10期
关键词：
children; Guinea-Bissau; hepatitis B; prevalence; transmission; West Africa; B-VIRUS INFECTION; EPIDEMIOLOGY;
D O I：
10.1111/tmi.14045
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objectives: This study reports on the prevalence of hepatitis B virus (HBV) in children in Guinea-Bissau before the hepatitis B vaccine was introduced. Methods: Cross-sectional study. From 2005 to 2008, 187 children aged 18 months were enrolled in a vaccine trial and had blood samples taken to test for HBV (HbsAg, anti-HBs and anti-HBc), hepatitis C virus (HCV) and HIV. Results: HBsAg prevalence was 11.2% and prevalence of any HBV serological marker was 16.0%. No children were positive for HCV. One was positive for HIV-1. Conclusions: The prevalence of HBsAg was high compared to other sub-Saharan African countries pre-immunisation, underscoring the importance of broad and sustained HBV vaccination. This study indicates that the majority of HBV transmission is horizontal during childhood in Guinea-Bissau.
引用
收藏
页码：919 / 921
页数：3
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