A case of pagetoid spread of urothelial carcinoma with notable reduction achieved through enfortumab vedotin, resulting in complete surgical resection

被引：0

作者：

Tokuoka, Kenichi ^{[1
,2
]}

Muramoto, Katsuki ^{[1
,2
]}

Sakanaka, Keigo ^{[1
,2
]}

Yoshihara, Kentaro ^{[1
]}

Yamamoto, Shutaro ^{[2
]}

Imai, Yu ^{[1
]}

Iwatani, Kosuke ^{[2
]}

Tashiro, Kojiro ^{[2
]}

Murakami, Masaya ^{[1
]}

Harada, Tohru ^{[3
]}

Hayashimoto, Takuya ^{[3
]}

Umemori, Miyaka ^{[4
]}

Kimura, Takahiro ^{[2
]}

Shimomura, Tatsuya ^{[1
,2
]}

Urabe, Fumihiko ^{[1
,2
]}

机构：

[1] Jikei Univ, Dept Urol, Hosp 3, 4-11-1 Izumihoncho, Komae, Tokyo 2018601, Japan

[2] Jikei Univ, Sch Med, Dept Urol, 3-25-8 Nishi Shimbashi,Minato Ku, Tokyo 1058471, Japan

[3] Jikei Univ, Hosp 3, Dept Pathol, 4-11-1 Izumihoncho, Komae, Tokyo 2018601, Japan

[4] Juntendo Univ, Dept Clin Lab Technol, 6-8-1 Hinode, Urayasu, Chiba 2790013, Japan

来源：

INTERNATIONAL CANCER CONFERENCE JOURNAL | 2024年 / 13卷 / 04期

关键词：

Enfortumab vedotin; Urothelial carcinoma; Extramammary Paget's disease; TRANSITIONAL-CELL CARCINOMA; GLANS-PENIS; DISEASE; SECONDARY; BLADDER; ORIGIN;

D O I：

10.1007/s13691-024-00720-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Secondary extramammary Paget's disease is a rare condition associated with the contiguous extension of tumor cells from the underlying adnexal structures, genitourinary, or gastrointestinal tracts. We report the case of an 80-year-old female with a 7-year history of urothelial carcinoma who presented with erythema of the labia majora. The diagnosis was pagetoid spread of urothelial carcinoma. The patient declined surgical resection of the lesion. She underwent nine cycles of first-line platinum-based chemotherapy and received one course of pembrolizumab for metastatic urothelial carcinoma. As the lesion progressively enlarged, third-line therapy with enfortumab vedotin was initiated, which resulted in significant tumor reduction. This allowed for a successful surgical complete resection of the tumor. Enfortumab vedotin was highly effective and demonstrated dramatic efficacy for controlling extramammary Paget's disease secondary to urothelial carcinoma.

引用

页码：510 / 514

页数：5

共 1 条

[1] Complete Response to Enfortumab Vedotin in a Hemodialysis Patient with Metastatic Urothelial Carcinoma: A Case Report
Isoda, Bunpei
Shiga, Masanobu
Kandori, Shuya
Nagumo, Yoshiyuki
Yoshino, Takayuki
Ikeda, Atsushi
Kawahara, Takashi
Kimura, Tomokazu
Negoro, Hiromitsu
Hoshi, Akio
Mathis, Bryan J.
Nishiyama, Hiroyuki
CASE REPORTS IN ONCOLOGY, 2023, 16 (01): : 429 - 433

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