Roles of the components of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori

被引：2

作者：

Gou, Lingzhu ^{[1
,3
]}

Yang, Xiaoping ^{[1
,3
]}

Yun, Jianwei ^{[1
]}

Ma, Zenghui ^{[1
,3
]}

Zheng, Xiaofeng ^{[1
]}

Du, Hongwei ^{[2
]}

Zhang, Dekui ^{[1
,3
]}

机构：

[1] Lanzhou Univ Second Hosp, Dept Gastroenterol, Lanzhou, Peoples R China

[2] Second Peoples Hosp Lanzhou City, Dept Gastroenterol, Lanzhou, Peoples R China

[3] Lanzhou Univ Second Hosp, Dept Gastroenterol, Key Lab Digest Dis, Lanzhou, Peoples R China

来源：

FUTURE MICROBIOLOGY | 2024年 / 19卷 / 14期

关键词：

Cag-T4SS; CagL; cagPAI; CagY; Helicobacter pylori; HELICAL RGD MOTIF; CRYSTAL-STRUCTURE; VIRULENCE FACTORS; GASTRIC-CANCER; PROTEIN; TRANSLOCATION; ASSOCIATION; INTEGRIN; INDUCTION; ADHESION;

D O I：

10.1080/17460913.2024.2383514

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Helicobacter pylori (H. pylori) cytotoxin-associated gene pathogenicity island (cagPAI) encodes 31 genes that assemble the cag type IV secretion system (T4SS) apparatus, which includes structures such as the outer membrane core complex, periplasmic ring, inner membrane complex and bacterial hairs. These proteins interact with each other to inject CagA into the host gastric epithelium. There are also individual unique functions that help H. pylori interfere with host cellular pathways, modulate the immune response and colonize the host for a long time. However, the functions of some of the proteins remain unclear. This review summarizes what is known about the structure and function of these auxiliary components and discusses their role in H. pylori pathogenesis.

引用

页码：1253 / 1267

页数：15

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