Unexpected metabolic effects of sodium-glucose cotransporter 2 inhibitors

被引：1
作者：
Drueke, Tilman B. [1 ,2 ]
Massy, Ziad A. [1 ,2 ,3 ,4 ]
机构：
[1] Paris Sud Univ UPS, Hop Paul Brousse, Inserm Unit 1018, Team 5,CESP, Villejuif, France
[2] Paris Ile De France Ouest Univ, UVSQ, Versailles St Quentin En Yvelines Univ, Villejuif, France
[3] Assoc Utilisat Rein Artificiel Reg Parisienne AURA, Paris, France
[4] Ambroise Pare Univ Hosp, APHP, Dept Nephrol, Paris, France
来源：
KIDNEY INTERNATIONAL | 2024年 / 106卷 / 01期
关键词：
cardiovascular disease; chronic kidney disease; microbiology; proximal tubule; uremic toxins;
D O I：
10.1016/j.kint.2024.03.005
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：12 / 15
页数：4
相关论文
共 9 条
[1]   Metabolic Communication by SGLT2 Inhibition [J].
Billing, Anja M. ;
Kim, Young Chul ;
Gullaksen, Soren ;
Schrage, Benedikt ;
Raabe, Janice ;
Hutzfeldt, Arvid ;
Demir, Fatih ;
Kovalenko, Elina ;
Lasse, Moritz ;
Dugourd, Aurelien ;
Fallegger, Robin ;
Klampe, Birgit ;
Jaegers, Johannes ;
Li, Qing ;
Kravtsova, Olha ;
Crespo-Masip, Maria ;
Palermo, Amelia ;
Fenton, Robert A. ;
Hoxha, Elion ;
Blankenberg, Stefan ;
Kirchhof, Paulus ;
Huber, Tobias B. ;
Laugesen, Esben ;
Zeller, Tanja ;
Chrysopoulou, Maria ;
Saez-Rodriguez, Julio ;
Magnussen, Christina ;
Eschenhagen, Thomas ;
Staruschenko, Alexander ;
Siuzdak, Gary ;
Poulsen, Per L. ;
Schwab, Clarissa ;
Cuello, Friederike ;
Vallon, Volker ;
Rinschen, Markus M. .
CIRCULATION, 2024, 149 (11) :860-884
[2]   Reno- and cardioprotective molecular mechanisms of SGLT2 inhibitors beyond glycemic control: from bedside to bench [J].
Chen, Xin ;
Hocher, Carl-Friedrich ;
Shen, Linghong ;
Kraemer, Bernhard K. ;
Hocher, Berthold .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2023, 325 (03) :C661-C681
[3]   SGLT2 inhibitors, sodium and off-target effects: an overview [J].
De Pascalis, Antonio ;
Cianciolo, Giuseppe ;
Capelli, Irene ;
Brunori, Giuliano ;
La Manna, Gaetano .
JOURNAL OF NEPHROLOGY, 2021, 34 (03) :673-680
[4]   Cardiac mechanisms of the beneficial effects of SGLT2 inhibitors in heart failure: Evidence for potential off-target effects [J].
Dyck, Jason R. B. ;
Sossalla, Samuel ;
Hamdani, Nazha ;
Coronel, Ruben ;
Weber, Nina C. ;
Light, Peter E. ;
Zuurbier, Coert J. .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022, 167 :17-31
[5]   Uremic Toxins and Cardiovascular Risk in Chronic Kidney Disease: What Have We Learned Recently beyond the Past Findings? [J].
El Chamieh, Carolla ;
Liabeuf, Sophie ;
Massy, Ziad .
TOXINS, 2022, 14 (04)
[6]   The Impact of SGLT2 Inhibitors in the Heart and Kidneys Regardless of Diabetes Status [J].
Matthews, Jennifer ;
Herat, Lakshini ;
Schlaich, Markus P. ;
Matthews, Vance .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (18)
[7]   Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis [J].
Packer, Milton .
CIRCULATION, 2022, 146 (18) :1383-1405
[8]   SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes [J].
Schaub, Jennifer A. ;
AlAkwaa, Fadhl M. ;
McCown, Phillip J. ;
Naik, Abhijit S. ;
Nair, Viji ;
Eddy, Sean ;
Menon, Rajasree ;
Otto, Edgar A. ;
Demeke, Dawit ;
Hartman, John ;
Fermin, Damian ;
O'Connor, Christopher L. ;
Subramanian, Lalita ;
Bitzer, Markus ;
Harned, Roger ;
Ladd, Patricia ;
Pyle, Laura ;
Pennathur, Subramaniam ;
Inoki, Ken ;
Hodgin, Jeffrey B. ;
Brosius III, Frank C. ;
Nelson, Robert G. ;
Kretzler, Matthias ;
Bjornstad, Petter .
JOURNAL OF CLINICAL INVESTIGATION, 2023, 133 (05)
[9]   Warning: the unfortunate end of p-cresol as a uraemic toxin [J].
Vanholder, Raymond ;
Bammens, Bert ;
de Loor, Henriette ;
Glorieux, Griet ;
Meijers, Bjorn ;
Schepers, Eva ;
Massy, Ziad ;
Evenepoel, Pieter .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2011, 26 (05) :1464-1467
1